UJI DISOLUSI TERBANDING TABLET SALUT SELAPUT RIFAMPISIN ANTARA TABLET INOVATOR DENGAN TABLET GENERIK DAN BERMEREK YANG BEREDAR DI PASARAN

Wicaksana, Bagas Adi (2017) UJI DISOLUSI TERBANDING TABLET SALUT SELAPUT RIFAMPISIN ANTARA TABLET INOVATOR DENGAN TABLET GENERIK DAN BERMEREK YANG BEREDAR DI PASARAN. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Rifampicin is an antibiotic drug and effective for the treatment of tuberculosis caused by Mycobacterium tuberculosis. Rifampicin included biopharmaceutical Classification System ( BCS ) class II with high permeability but a low solubility properties. It is available commercially in the preparation of generic and innovator, and therefore caused the different formulations and method of fabrication. This study aims to determine the physical quality and rifampicin dissolution profile between innovator with several brands are spread in the market. Test products using five products rifampicin 450 mg tablets in the market, that one innovator product A, two brand products B and C, and two generic products D and E. Dissolution testing using dissolution apparatus type 2 (paddle) rotation speed of 50 rpm in 900 ml of the dissolution medium. Dissolution medium is used HCl solution pH 1.2. The dissolution assay using a UV-Vis spectrophotometer at a wavelength of 470 nm. The Result of research for physical qualities were uniformity of weight, hardness, and disintegrate time showed that all of rifampicin tablet products had difference and fulfilled of established requiments. The result of Q45 value showed that generic A, brand B, and generic D qualified more than 75%. Brand B and generic D products showed that F1 value less than 15% and F2 value more than 50% so dissolution profiles were similar with innovator A. Keywords : Rifampicin, innovator, brand, generic, physical quality, dissolution

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Rifampicin, innovator, brand, generic, physical quality, dissolution
Subjects:	R Medicine > R Medicine (General)
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Rohma Tri Wardani
Date Deposited:	23 Feb 2019 04:27
Last Modified:	23 Feb 2019 04:27
URI:	http://repo.setiabudi.ac.id/id/eprint/946

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