UJI ANTIINFLAMASI EKSTRAK ETANOL DAUN PEPAYA (Carica papaya Linn) PADA TIKUS PUTIH JANTAN GALUR WISTAR YANG DI INDUKSI KARAGENIN

Afandi, Mukhamad (2017) UJI ANTIINFLAMASI EKSTRAK ETANOL DAUN PEPAYA (Carica papaya Linn) PADA TIKUS PUTIH JANTAN GALUR WISTAR YANG DI INDUKSI KARAGENIN. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Inflammatory is a response toward damaged tissue due to several harm stimulations either chemicals or mechanics, and infection from bacteria or virus. Carica papaya leaf contais saponin and flavonoid. This research aimed at determining the anti-inflammatory effect of papaya ethanolic extract on Wister male rat that has been induced carrageenan and determining the doses variations of papaya leaf extract on the effect of anti-inflammation. Papaya (Carica papaya L.)was extracted by maceration method using ethanol 96%. The anti-inflammatory effect testing was done using 25 rats with edema method on bottom part of foot that has been induced by carrageenan 1%. The animal model was divided by five groups one. Na CMC 1%, papaya leaf ethanolic extract of 70, 210, 420 mg/kg BW, and diclofenac sodium for group 1,2,3,4, and 5, respectively. The measurement was conducted after one hour of 1% of carrageenan induction on bottom part of foot intraplantarly. The results were measured during five hours and calculated AUC value and percentage of anti-inflammatory activity. The result showed that papaya leaf ethanolic extract had anti-inflammatory activity on Wistar male rats. The doses of papaya leaf ethanolic extract of 70, 210, 420 mg/200 g BW had anti-inflammatory activity of 21,68%, 38,61%, and 49,03%, respectively. The doses of papaya leaf ethanolic extract of anti-inflammation activity closed to diclofenac sodium. The papaya dose of 420 mg/200 g BW had the most effective anti-inflamatory. Keywords: anti-inflammation, papaya leaf ethanolic extract, carrageenan

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Keywords: anti-inflammation, papaya leaf ethanolic extract, carrageenan
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Herera Gadys USB
Date Deposited:	25 Feb 2019 02:56
Last Modified:	25 Feb 2019 02:56
URI:	http://repo.setiabudi.ac.id/id/eprint/955

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