AKTIVITAS ANTIPARKINSON EKSTRAK RIMPANG TEMULAWAK (Curcuma xathorriza Roxb.) PADA TIKUS PUTIH (Rattus norvegicus) GALUR Sprague dawley YANG DIINDUKSI HALOPERIDOL

Anitasari, Nofika Dwi (2017) AKTIVITAS ANTIPARKINSON EKSTRAK RIMPANG TEMULAWAK (Curcuma xathorriza Roxb.) PADA TIKUS PUTIH (Rattus norvegicus) GALUR Sprague dawley YANG DIINDUKSI HALOPERIDOL. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Temulawak (Curcuma xathorriza Roxb.) Is a plant that contains curcumin. Curcumin in ethanol extracts of temulawak rhizome has been shown to penetrate the blood brain barrier and has a neuroprotective effect that can reduce the symptoms of parkinsonism caused by haloperidol. This study aims to determine the activity of ethanol extract of temulawak rhizome in reducing symptoms of Parkinson's. This study used 35 rats divided into 7 groups, each group consisting of 5 rats. Group 1 was given aquadestilata. Group II was given a solution of 0.5% CMC-Na. Group III was given levodopa dose 27 mg/kgBB p.o. Group IV was given vitamin E dose of 180 IU/kgBB p.o. Groups V, VI, VII were given the temulawak extracts of 120, 240 and 480 mg/kgBB p.o. 45 minutes later all groups except group I were given haloperidol 2 mg/kgBB i.p. The catalepsy and rota rod tests were performed on days 0, 4, 7, 11 and 14. In the catalepsy test it was xvii recorded when the test animals improved their posture and then interpreted in the score. While the rota rod test recorded when the animal test when dropped (latency). From catalepsy test of temulawak extract dose 120, 240, 480 mg/kgBB respectively showed activity of 25,68%, 52,97%, and 58,98%. While in rota rod test showed the activity of 26,87%, 26,16% and 33,19% respectively. The ethanol extract of the ginger rhizomes (Curcuma xathorriza Roxb.) may reduce the occurrence of haloperidol-induced parkinsonism symptoms. Keywords: temulawak, curcuma, kurkumin, catalepsy, rota rod

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	temulawak, curcuma, kurkumin, catalepsy, rota rod
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Herera Gadys USB
Date Deposited:	25 Feb 2019 03:00
Last Modified:	25 Feb 2019 03:00
URI:	http://repo.setiabudi.ac.id/id/eprint/978

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