Kusmahendra, Dian Christivan (2017) SINTESIS SENYAWA ANALOG KALKON DENGAN MATERIAL AWAL Ρ-METOKSIASETOFENON DAN INDOL-3-KARBALDEHID MENGGUNAKAN KATALIS NaOH DALAM TEMPERATUR KAMAR (27ᴼ C-30ᴼ C). Skripsi thesis, Universitas Setia Budi Surakarta.
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Abstract
Chalcones are considered as the precursors of flavonoids which consist of two aromatic rings linked by a three-carbon α,β-unsaturated carbonyl system. Chalcone and its analogues have been reported to possess various biological activities such as antibacterial, anticancer, antifungal, anti-inflammatory and antioxidant. The aim of this study was to synthesize 3-(3-indolyl)-1-(4methoxyphenyl)prop-2-en-1-one using indole-3-carboxaldehyde and ρ-methoxyacetophenone as starting materials. 3-(3-indolyl)-1-(4-methoxyphenyl)prop-2-en-1-one was synthetized from indole-3carboxaldehyde and ρ-methoxyacetophenone, catalyzed by NaOH in room temperature (27 - 30ᴼ C). Thin layer and gas chromatography were used as purity test method. The structure of the compound was elucidated using mass spectrometer, UV-Vis spectrophotometer and IR spectrophotometer. The resultsshowedthat 3-(3-indolyl)-1-(4-methoxyphenyl)prop-2-en-1-one wassuccessfullysynthesized, yellow powder was obtained with 3,11% of yield and 90,19 % of purity. Structure elucidation showed that the chemical structure was appropriate to estimated chemical structure. Keywords: synthesis, 3-(3-indolyl)-1-(4- methoxyphenyl)prop-2-en-1-one, NaOH, indole-3-carboxaldehyde,ρ-methoxyacetophenone, chalcone analogue
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | synthesis, 3-(3-indolyl)-1-(4- methoxyphenyl)prop-2-en-1-one, NaOH, indole-3-carboxaldehyde,ρ-methoxyacetophenone, chalcone analogue |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Fakultas Farmasi > Prodi S1 Farmasi |
| Depositing User: | Rohma Tri Wardani |
| Date Deposited: | 25 Feb 2019 03:02 |
| Last Modified: | 25 Feb 2019 03:02 |
| URI: | http://repo.setiabudi.ac.id/id/eprint/985 |
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