Khairunnisa, Ida Zulfia (2016) PERBEDAAN KADAR HEMOGLOBIN A1c ANTARA METODE HPLC (HIGH PERFORMANCE LIQUID CHROMATOGRAPHY) DAN CAPILLARY ELECTROPHORESIS PADA DIABETES MELITUS TIPE 2. Skripsi thesis, Universitas Setia Budi Surakarta.
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Abstract
A1c hemoglobin is a bound of Hb and glucose. Diabetes Mellitus Type 2 is a metabolic disorder with an increase of blood glucose level resulting from a decrease of insulin caused by pancreatic beta cell or insulin resistance. This study aims at investigating the difference in HbA1c levels when examined using HPLC method and using CE method. This research applied analytical comparative study with cross-sectional design, which was carried out from 5 April to 6 April 2016 using 30 samples at dr. Moewardi Regional Public Hospital (RSUD) in Surakarta. The statistical analysis is significant when p (<0.05) with confidence interval of 95%. Paired sample t-test results in the p value of 0.059 (>0.05), meaning that there is no significant difference on the average score for the examination results of HbA1c levels whether calculated using HPLC method or CE method, with 13 men (43.3) and 17 women (56.7) . The average score for standard deviation of HbA1c level examined using HPLC method is ± 8.2 ± 1.8%, and the average score for standard deviation of HbA1c examined using CE method is 8.1 ± 1.7%. On the basis of the research results, it can be concluded that there is no significant difference of HbA1c levels when measured using HPLC method and CE on Diabetes Mellitus Type 2, with probability value of p=0.059. It is suggested that further researches with different research design and which compare HbA1c levels using different methods need to be carried out. Keywords: HbA1c level, High performance liquid chromatography, Capillary Electrophoresis.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | HbA1c level, High performance liquid chromatography, Capillary Electrophoresis. |
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Fakultas Ilmu Kesehatan > Prodi D4 Analis Kesehatan |
| Depositing User: | Tifany Nur Arfiana |
| Date Deposited: | 10 Oct 2019 08:20 |
| Last Modified: | 10 Oct 2019 08:20 |
| URI: | http://repo.setiabudi.ac.id/id/eprint/1853 |
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