Setiawan, Rendy (2014) FORMULASI SEDIAAN TABLET SALBUTAMOL DENGAN VARIASI KONSENTRASI NA-CMC DAN EXPLOTAB® DENGAN METODE GRANULASI BASAH. Karya Tulis Ilmiah thesis, Universitas Setia Budi Surakarta.
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Abstract
Salbutamol is one of the many drugs that have benefit for the treatment of bronchial asthma. Salbutamol in this study were made into a tablet dosage. Expected to make a tablet of salbutamol with Na-CMC binder and material crusher Explotab ® who meet physical quality according persyarataan, as well as knowing the concentration of Na-CMC and Explotab ® that provides physical quality of salbutamol tablets most good. The salbutamol table was prepared using wet granulation method. Granulation was made in three formulations: formula I (Na-CMC 3% and Explotab® 5%), formula II (Na-CMC 4% and Explotab® 4%), and formula III (Na-CMC 5% and Explotab® 3%. Dry granule was examined first for drying shrinkage and flow time before it was pressed into tablet, while the granule pressed into tablet was tested for its physical quality including: weigh uniformity, stringency, brittleness, and destruction time. The result of research was then compared with the conditions specified by the third edition of Farmakope Indonesia and other literatures. The data was analyzed statistically with a one-way anova at confidence interval of 95%. The result of research showed that salbutamol could be made table preparation. Sabultamol tablet preparation with concentrations of Na-CMC 3% and Explotab ® 5%, Na-CMC 4% and Explotab® 4%, and Na-CMC 5% and Explotab® 3% met the conditions of physical quality test for tablet. The tablet preparation with Na-CMC 3% and Explotab ® 5% concentration was the best formula. Keywords: Tablet, Salbutamol, Na-CMC, Explotab®, Wet Granulation
| Item Type: | Thesis (Karya Tulis Ilmiah) |
|---|---|
| Uncontrolled Keywords: | Tablet, Salbutamol, Na-CMC, Explotab®, Wet Granulation |
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Fakultas Farmasi > Prodi D3 Farmasi |
| Depositing User: | magdalena kartika ningsih |
| Date Deposited: | 21 Feb 2020 03:33 |
| Last Modified: | 21 Feb 2020 03:33 |
| URI: | http://repo.setiabudi.ac.id/id/eprint/2760 |
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