UJI AKTIVITAS TONIKUM EKSTRAK DAN FRAKSI HERBA SAMBILOTO (Andrographis paniculata Nees.) PADA MENCIT PUTIH JANTAN (Mus musculus)

Sari, Anisa Desty Fitria (2024) UJI AKTIVITAS TONIKUM EKSTRAK DAN FRAKSI HERBA SAMBILOTO (Andrographis paniculata Nees.) PADA MENCIT PUTIH JANTAN (Mus musculus). Skripsi thesis, Universitas Setia Budi.

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Abstract

ANISA DESTY FITRIA SARI, 2023, TEST OF TONICUM ACTIVITIES OF SAMBILOTO HERB (Andrographis paniculata Nees.) EXTRACT AND FRACTIONS ON MALE WHITE MICE (Mus musculus), SKRIPSI, FACULTY OF PHARMACEUTICAL, SETIA BUDI UNIVERSITY, SURAKARTA. Supervised by Dr. apt. Ika Purwidyaningrum, S.Farm., M.Sc. and apt Ghani Nurfiana Fadma Sari, M.Farm. Tonics are preparations or drugs that increase endurance. Sambiloto herb contains saponin, flavonoid, tanin and diterpene compounds whose main component is andrographolide. This research aims to determine the tonic effect, the most active fraction from the water fraction, ethyl acetate and n-hexane of the bitter herbs as well as the group of compound in the active fraction. Sambiloto herb powder was macerated using 70% ethanol, and fractionated using water, ethyl acetate, and n-hexane. The tonic activity test used the hanging method with 24 mice as test animal. Negative control Na-CMC 0,5 % (I), positive control caffeine 100 mg/KgBB (II), sambiloto herb extract with a dose of 74,554 mg/KgBB (III), n-hexane fraction with a dose of 3,18 mg/KgBB (IV), ethyl acetate fraction with a dose of 3,67 mg/KgBB (V), water fraction with a dose of 44,08 mg/KgBB (VI). The results of the data obtained in the tonic effect test from the time difference before administration (T0) and after administration (T1) were analyzed statistically using One Way ANOVA. The n-hexane fraction, ethyl acetate fraction, and water fraction have tonic activity. The ethyl acetate fraction with a dose of 3,67 mg/KgBB is the most active fraction and has a tonic effect comparable to caffeine 100 mg/KgBB. The flavonoid and alkaloid compound contained in the active fraction are though to play a role in the tonic effect.

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Tonikum, fraksi herba sambiloto (Andrographis paniculata Nees.), Gelantung,Tonic, Sambiloto herb fraction (Andrographise paniculata Nees.), Hanging
Subjects:	Q Science > Q Science (General) R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	USB
Date Deposited:	20 Jun 2024 02:45
Last Modified:	20 Jun 2024 02:45
URI:	http://repo.setiabudi.ac.id/id/eprint/6224

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