Sumariadi, Wahyu Gelorawan (2015) PENGARUH PEMBERIAN EKSTRAK ETANOL 96% DAUN KANGKUNG DARAT (Ipomoea reptana Poir.) TERHADAP ONSET DAN DURASI EFEK SEDASI PADA MENCIT PUTIH JANTAN (Mus musculus). Karya Tulis Ilmiah thesis, Universitas Setia Budi Surakarta.
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Abstract
Kale (Ipomea reptana Poir.) is traditional medicinal plant which was believed society could be used as a sleeping pill. The study purpose was determined the effect of kale leaf extract on the onset and sedation effect duration on male white mice and effective dose of 96% ethanol extract of the kale leaves extract as sedation effects on male white mice. This study was used 25 male white mice, were divided into 5 groups. Positive control group were treated with phenobarbital, negative control group were treated with solution of 1% CMC and 3 groups were given kale leaf extract at a dose of 6 mg/20 gBW, 12 mg/20 gBW and 24 mg/20 gBW. Giving done orally, then observed and recorded the onset time and sedation duration. The results of the average onset time and sedation duration were indicated that 96% ethanol of kale leaf extract can accelerate the onset time and extended the sedation effect duration on male white mice (Mus musculus). The most effective dose of 96% ethanol of kale leaves extract as sedation effects on male white mice is 24 mg/20 gBW. Keywords: leaves of kale (Ipomoea reptana Poir.), 96% ethanol extract, sedation
| Item Type: | Thesis (Karya Tulis Ilmiah) |
|---|---|
| Uncontrolled Keywords: | leaves of kale (Ipomoea reptana Poir.), 96% ethanol extract, sedation |
| Subjects: | Q Science > QD Chemistry R Medicine > RS Pharmacy and materia medica |
| Divisions: | Fakultas Farmasi > Prodi D3 Farmasi |
| Depositing User: | magdalena kartika ningsih |
| Date Deposited: | 15 Nov 2019 07:04 |
| Last Modified: | 15 Nov 2019 07:04 |
| URI: | http://repo.setiabudi.ac.id/id/eprint/2183 |
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