AKTIVITAS ANTIDIABETES EKSTRAK ETANOL DAUN SIRIH MERAH (Piper crocatum) PADA TIKUS DM RESISTEN INSULIN

Lia, Bunga (2019) AKTIVITAS ANTIDIABETES EKSTRAK ETANOL DAUN SIRIH MERAH (Piper crocatum) PADA TIKUS DM RESISTEN INSULIN. Skripsi thesis, Universitas Setia Budi.

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Abstract

Diabetes mellitus (DM) is a metabolic disease that has the characteristics of hyperglycemia which can cause abnormal insulin secretion. Piper crocatum are proven to contain compounds of flavonoids, alkaloids, tannins, saponins, and essential oils where these compounds are efficacious as antidiabetic. This study aims to prove the antidiabetic activity of piper crocatum extract in type-2 DM rats that experience insulin resistance. This study used 36 test animals divided into two treatment groups. Six rats in the normal control group were not treated and 30 rats were divided into five groups and given insulin1.8 IU / KgBW / day for 14 days. Group I controlled 0.5% CMC-Na 0,5%, group II metformin 9 mg / KgBW positive control, group III piper crocatum extract 50 mg / KgBB, group IV piper betel leaf extract 100 mg / KgBB, and group V leaf extract piper crocatum 200 mg / KgBw for 14 days. Examination of antidiabetic effects is done by comparing the GDP value of rats before and after treatment. Data on the decrease in GDP are tested by statistical data. The results from the V group differed significantly, indicating that there was an antidiabetic effect of piper crocatum leaf extract. Type-2 DM rats in positive control were comparable to the variation in dose of piper betel leaf extract 200 mg /KgBW. Keywords: Diabetes Melitus, Piper betel leaf (Piper crocatum), Insulin resistance.

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: Diabetes Melitus, Piper betel leaf (Piper crocatum), Insulin resistance.
Subjects: Q Science > QK Botany
Divisions: Fakultas Farmasi > Prodi S1 Farmasi
Depositing User: Tifany Nur Arfiana
Date Deposited: 01 Nov 2019 03:33
Last Modified: 01 Nov 2019 03:33
URI: http://repo.setiabudi.ac.id/id/eprint/3576

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