PENGARUH KONSENTRASI Na-CMC PADA SEDIAAN EMULGEL EKSTRAK ETANOL DAUN BANDOTAN (Agerantum conyzoides L) TERHADAP SIFAT FISIK DAN PENYEMBUHAN INFEKSI Staphylococcus aureus ATCC 25923 SECARA in vivo

Putranto, Cesar Nurcahyo Putranto (2019) PENGARUH KONSENTRASI Na-CMC PADA SEDIAAN EMULGEL EKSTRAK ETANOL DAUN BANDOTAN (Agerantum conyzoides L) TERHADAP SIFAT FISIK DAN PENYEMBUHAN INFEKSI Staphylococcus aureus ATCC 25923 SECARA in vivo. Skripsi thesis, Universitas Setia Budi.

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Abstract

Extract ethanol of Bandotan leaves ( Ageratum conyzoides L) having an antibacterial activity of Staphylococcus aureus. Emulgel is a topical preparation that will improve the efficacy of treatment and convenience. Physical properties and effective treatment in emulgel affected by several factors one of them is a gelling agent. Na-CMC is one type of gelling agent. The purpose of this research is to find the influence variation concentration Na-CMC against the character of physical and healing infections of Staphylococcus aureus ATCC 25923. Emulgel formulated into three formula that is Na-CMC 2 %, 3 %, and 4 % use ethanol extract of Bandotan leaves with concentration 20 % every formula. The physical properties include the organoleptic, homogeneity, pH, viscosity, attaching, spreadability and stability. The healing infection test uses 5 rabbits who infected by the suspension of the Staphylococcus aureus ATCC 25923 on 5 locations in the rabbits’ back. In 5 locations smeared with ethanol extract of Bandotan leaves and emulgel with Na-CMC 2%, 3%, 4%, in positive and negative controls, then the healing time was observed. Physical properties test analyzed by two-way ANOVA and healing time with one way ANOVA. The results showed that the variation of Na-CMC concentrations affected the physical properties and healing of Staphylococcus aureus ATCC 25923 infections. The emulgel formula of Bandotan leaves ethanol extract with 3% Na-CMC showed good physical properties and the fastest healing effect compared to 2% and 4% Na-CMC formula, with 9-11 days of healing time. Key word: Bandotan leaves extract (Agerantum conyzoides L), Emulgel, NaCMC, Staphylococcus aureus ATCC 25923

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Bandotan leaves extract (Agerantum conyzoides L), Emulgel, NaCMC, Staphylococcus aureus ATCC 25923
Subjects:	Q Science > QK Botany
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	01 Nov 2019 03:34
Last Modified:	01 Nov 2019 03:34
URI:	http://repo.setiabudi.ac.id/id/eprint/3580

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