Mukti, Indra (2019) UJI EFEK ANALGETIK EKSTRAK ETANOL DAUN SINGKONG (Manihot utilissima) PADA MENCIT PUTIH JANTAN (Mus musculus). Karya Tulis Ilmiah thesis, Universitas Setia Budi Surakarta.
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Abstract
Cassava leaves (Manihot utilissima) are plants that have many benefits among them, namely as analgesic. The main content is flavonoids, flavonoids are efficacious as an analgesic whose mechanism of action inhibits the work of the cyclooxygenase enzyme. This research aims to determine the analgetic effect of cassava leaf extract on male white mice The research was conducted using maceration method with ethanol solvent 70%, in which cassava leaves powder was put into maceration vessel and added with 3000 ml ethanol solvent, then filtrate was evaporated using evaporator resulting in extract that was then concentrated using oven obtain thick extract. The thick extract yielded was trialed on male white mice (Mus musculus). Tested animals were divided into 5 groups, each of which consisted of 5 male white mice (Mus musculus). Group I serving as positive control used aspirin, group II serving as negative control used CMC 0.5%, group III used dose of 25.65 mg/kg BW, group IV used dose of 38.4 mg/kg BW, and group V used dose of 51.2 mg/kg BW. The number of wriggle was calculated once in 10 minutes for 60 minutes. The data obtained was then analyzed using one-way ANAVA and Duncan. The result of research showed that cassava leaves ethanol extract had analgetic effect on male white mice, as indicated with percentage analgetic power of > 50% and and with statistical tests. The dose of cassava leaves ethanol extract exerting analgetic effect was 25,65 mg/kg BW. Keywords: cassava leaves, maceration, analgetic.
| Item Type: | Thesis (Karya Tulis Ilmiah) |
|---|---|
| Uncontrolled Keywords: | cassava leaves, maceration, analgetic. |
| Subjects: | Q Science > QK Botany R Medicine > RS Pharmacy and materia medica |
| Divisions: | Fakultas Farmasi > Prodi D3 Farmasi |
| Depositing User: | Mrs NOVI HANDAYANI |
| Date Deposited: | 16 Nov 2019 02:26 |
| Last Modified: | 16 Nov 2019 02:26 |
| URI: | http://repo.setiabudi.ac.id/id/eprint/3758 |
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