OPTIMASI NATRIUM KARBOKSI METIL SELULOSA (Na-CMC) DAN KARBOPOL 941 PADA SEDIAAN GEL DISPERSI PADAT IBUPROFEN DENGAN METODE SIMPLEX LATTICE DESIGN

Rohmayanti, Maulidah (2020) OPTIMASI NATRIUM KARBOKSI METIL SELULOSA (Na-CMC) DAN KARBOPOL 941 PADA SEDIAAN GEL DISPERSI PADAT IBUPROFEN DENGAN METODE SIMPLEX LATTICE DESIGN. Skripsi thesis, Universitas Setia Budi.

	Text INTISARI.pdf Download (524kB)
	Text FORM PUBLIKASI-Copy.pdf Download (357kB)
	Text COVER-BAB I.pdf Download (1MB)
	Text BAB II.pdf Restricted to Repository staff only Download (1MB) | Request a copy
	Text BAB III.pdf Restricted to Repository staff only Download (830kB) | Request a copy
	Text BAB IV.pdf Restricted to Repository staff only Download (1MB) | Request a copy
	Text BAB V-LAMPIRAN.pdf Download (4MB)

Abstract

Ibuprofen is a non-steroid anti inflammatory drug (NSAID) used for painful and inflammation. Ibuprofen gel is an effective approach evading ibuprofen's side effect in GI tract and first pass effect. This research was to determine and know the gel optimum formula based on the physical properties of viscosity, dispersive power, adhesion with Simplex Lattice Design. Gel preparations were made using a base of Carboxymethylcellulose Sodium (CMC-Na) and carbopol 941. Three types of formula are made F1 (Na�CMC 100% ), F2 (Na-CMC 50%: Carbopol 941 50%), F3 (Carbopol 941 100%) optimized based on the physical properties of viscosity, dispersive power, adhesion with Simplex Lattice Design optimization methods using trial version software Design Expert v. 10.1. The gel evaluations were organoleptic testing, homogenity, pH, viscosity, dispersive power, and adhesion. Optimum gel formula was tested verification based on the physical properties of viscosity, dispersive power, adhesion and stability with cycling test method. The optimum formula of ibuprofen solid dispersion gel obtained with proportion of 3% Na-CMC and 0% Carbopol 941. Response to the physical properties of the optimum formula as predictions and experimental results showed a not significant difference and not show discoloration and phase separation after six stability cycles of testing. Keywords : Simplex lattice design, Na-CMC, carbopol 941, ibuprofen, cycling test

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Simplex lattice design, Na-CMC, carbopol 941, ibuprofen, cycling test
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	29 Mar 2022 07:55
Last Modified:	29 Mar 2022 07:55
URI:	http://repo.setiabudi.ac.id/id/eprint/4680

Actions (login required)

View Item