PENGARUH VARIASI KONSENTRASI GELLING AGENT Na CMC TERHADAP KARAKTERISASI SIFAT FISIK DAN PELEPASAN IBUPROFEN ATAU OBAT DENGAN KELARUTAN RENDAH DALAM SEDIAAN TOPIKAL BERDASARKAN STUDI DESKRIPTIF

Wardani, Hesty Pita (2020) PENGARUH VARIASI KONSENTRASI GELLING AGENT Na CMC TERHADAP KARAKTERISASI SIFAT FISIK DAN PELEPASAN IBUPROFEN ATAU OBAT DENGAN KELARUTAN RENDAH DALAM SEDIAAN TOPIKAL BERDASARKAN STUDI DESKRIPTIF. Skripsi thesis, Universitas Setia Budi.

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Abstract

Ibuprofen is a propionic acid derivative with dominant analgesic, antipyretic and anti-inflammatory effects reflecting an inhibition of prostaglandin synthesis. The use of ibuprofen orally has limitations in its use because it can cause effects on the digestive tract, especially gastric irritation until bleeding, so topical preparations are made. Other drugs included in the Biopharmaceutics Classiffication System II (BCS II) group such as tinidazole and sodium diclofenac have low solubility in water so that the absorption of the drug is not good. This descriptive study aims to determine the effect of variations in Na-CMC concentration as a gelling agent on the characterization of physical properties and the release of ibuprofen or drugs that have low solubility in topical preparation formulas based on the results of descriptive studies. This research was conducted by making semisolid preparations used topically by using variations in the concentration of Na CMC as a gelling agent. This preparation was then performed physical characterization test and drug release to determine the effect of variations in the concentration of Na CMC gelling agent based on the results of descriptive studies. The results of the descriptive study showed that variations in the concentration of Na CMC gelling agent had an effect on increasing the value of viscosity, adhesion, decreasing spreadability, and decreasing release of ibuprofen or drugs which had low solubility in topical preparations. The release of ibuprofen or drugs that have low solubility from topical preparations decreases with increasing concentrations of Na CMC gelling agent used Keywords: Ibuprofen, gelling agent, Na CMC, topical preparations, release test.

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Ibuprofen, gelling agent, Na CMC, topical preparations, release test.
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	09 Jun 2022 03:27
Last Modified:	09 Jun 2022 03:27
URI:	http://repo.setiabudi.ac.id/id/eprint/4756

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