OPTIMASI HIDROKSIPROPIL METILSELULOSA (HPMC) DAN KARBOPOL 940 PADA SEDIAAN GEL DISPERSI PADAT IBUPROFEN DENGAN METODE SIMPLEX LATICE DESIGN

Wahidah, Fauzah Lamh (2020) OPTIMASI HIDROKSIPROPIL METILSELULOSA (HPMC) DAN KARBOPOL 940 PADA SEDIAAN GEL DISPERSI PADAT IBUPROFEN DENGAN METODE SIMPLEX LATICE DESIGN. Skripsi thesis, Universitas Setia Budi.

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Abstract

Ibuprofen is a class of NSAIDs with analgesic and antipyretic properties. Ibuprofen has limited use because it has side effects in the digestive track including gastritic and gastrointestinal bleeding. Minimized side effect of ibuprofen by developing it in to gel-shaped transdermal preparation. Practically insoluble in water, soluble in aceton dichloretan, chloroform, and methanol; difficult to dissolve in ethyl acetate. The method use to improve its solubility is to make a ibuprofen – PEG 6000 solid dispersion in a ratio 1 : 1,5 using the melting method. The purpose of this research is to determine and find out the optimum formula base on the parameters of viscosty, spreadability and adhesion using the simplex lattice design method. Gel solid dispersion preparations were made using a base of hidroxypropyl methylcellulose (HPMC) and carbopol 940. Three types of formula that are made F1 (HPMC 100% ), F2 (HPMC 50%: Carbopol 940 50%), F3 (Carbopol 940 100%), then optimized based on 3 parameters viscosity, dispersive power, adhesion with Simplex Lattice Design optimization methods using trial version software Design Expert v. 10.1. The gel evaluations were organoleptic testing, homogenity, pH, viscosity, dispersive and adhesion. Optimum gel formula was tested verification based on the physical properties of viscosity, dispersive power, adhesion and stability with cycling test method. The optimum proportion of formula chosen is HPMC 1,73455% and Carbopol 940 0,26545%. The response of the physical propperties of the optimum formula to the prediction and research data was not significantly different. The optimum gel formula stability test results during the 6 cycles did not changes the color and phase separatation. Keywords : optimation, solid dispersion, ibuprofen, simplex lattice design

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	optimation, solid dispersion, ibuprofen, simplex lattice design
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	09 Jun 2022 03:29
Last Modified:	09 Jun 2022 03:29
URI:	http://repo.setiabudi.ac.id/id/eprint/4792

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