FORMULASI DAN OPTIMASI SEDIAAN SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM (SNEDDS) FUROSEMID DENGAN VARIASI KONSENTRASI MINYAK JARAK DAN TWEEN 80

Bahy, Angela Merici Saputry (2020) FORMULASI DAN OPTIMASI SEDIAAN SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM (SNEDDS) FUROSEMID DENGAN VARIASI KONSENTRASI MINYAK JARAK DAN TWEEN 80. Skripsi thesis, Universitas Setia Budi.

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Abstract

Furosemide is one of loop diuretic drugs that include tu BCS class IV. Furosemid has a poor solubility in water (0,01825 mg/mL) so it’s made in self-nanoemulsifying drug delivery system (SNEDDS) form to increase the solubility. The oil phase used is castor oil, surfactant phase is tween 80, and cosurfactant phase is PEG 400. The goals of this research are to know about the effect of castor oil and tween 80 variation concentration to furosemide SNEDDS characteristics, and to get the optimum formula between castor oil and tween 80 in forming stable furosemide SNEDDS. Independent variables of this research are castor oil and tween 80 concentrations. Seven furosemide SNEDDS formulas from Simplex Lattice Design method, tested their characteristics, includes percent transmittant, emulsification time, and drug loading. The result is optimized with Simplex Lattice Design. Optimal formula is characterizes again, include three tests before, plus zeta potential test, droplet size test, and disolution in vitro, characterisation results are compared to theoretical valued and analized with one Sample T-Test method. The result of this research showed that there are difference in the differences in chararacteristics of each furosemid SNEDDS formulas, that percent transmittance is most affected by tween 80 concentration, emulsification time and drug loading are most affected by castor oil consentration. The optimum formula was obtained 25,3% castor oil; 64,7% tween 80; 10% PEG 400, with characteristics include percent transmittant 87,9%; emulsification time 102,67 detik; drug loading 51335,55 ppm; zeta potential -23,9 mV; droplet size 11,35 nm; dan disolution in vitro 102,66% in one hour Keywords: SNEDDS, Furosemide, castor oil, tween 80

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	SNEDDS, Furosemide, castor oil, tween 80
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	09 Jun 2022 03:29
Last Modified:	09 Jun 2022 03:29
URI:	http://repo.setiabudi.ac.id/id/eprint/4802

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