KAJIAN NETWORK PHARMACOLOGY HERBA SAMBILOTO (Andrographis paniculata) TERHADAP PROTEIN TARGET DIABETES MELITUS TIPE 2

Novansyah, E. Aulia (2021) KAJIAN NETWORK PHARMACOLOGY HERBA SAMBILOTO (Andrographis paniculata) TERHADAP PROTEIN TARGET DIABETES MELITUS TIPE 2. Skripsi thesis, Universitas Setia Budi.

	Text 01.INTISARI_E. Aulia Novansyah_23175074A_S1 Farmasi.pdf Download (187kB)
	Text 04. BAB I_E. Aulia Novansyah_23175074A_S1 Farmasi.pdf Download (1MB)
	Text 05. BAB II_E. Aulia Novansyah_23175074A_S1 Farmasi.pdf Restricted to Repository staff only Download (539kB) | Request a copy
	Text 06. BAB III_E. Aulia Novansyah_23175074A_S1 Farmasi.pdf Restricted to Repository staff only Download (326kB) | Request a copy
	Text 07. BAB IV_E. Aulia Novansyah_23175074A_S1 Farmasi.pdf Restricted to Repository staff only Download (1MB) | Request a copy
	Text 08. BAB V_E. Aulia Novansyah_23175074A_S1 Farmasi.pdf Restricted to Repository staff only Download (184kB) | Request a copy
	Text 09. DAFTAR PUSTAKA_E. Aulia Novansyah_23175074A_S1 Farmasi.pdf Download (309kB)
	Text 10. LAMPIRAN_E. Aulia Novansyah_23175074A_S1 Farmasi.pdf Download (2MB)
	Text 02. PERNY PUBLI_E. Aulia Novansyah_23175074A_S1 Farmasi.pdf Download (594kB)
	Text 03. PERNY PLAGIASI_E. Aulia Novansyah_23175074A_S1 Farmasi.pdf Download (63kB)

Abstract

Type 2 diabetes mellitus has several protein targets as therapeutic targets. Sambiloto is a plant that is believed to have efficacy in overcoming diabetes mellitus. Traditional medicines from plants generally form complex interactions with many targets. network pharmacology is a method that can be used to reveal the complex interactions of a pathophysiological pathway. This study aims to determine the compounds in herbs that are able to interact with target protein, and to determine the pharmacology profile. This research uses cytoscape software to build network pharmacology. Sample in this study was the chemical content of the bitter herbs obtained from the knapsack database and the target protein was obtained from the SuperTarget database. Gene names are validated with database from uniprot and then look for protein-protein interactions using a String database. Interactions on String database with combined score of 0.9 and above were collected as data. All data that has been obtained are tabulated. Tabulated data is then imported into Cytoscape to build tissue pharmacology. The visualization result shows that caffeic acid and beta-sitosterol involved in DPP4 network as DPP4-inhibitor lead to inhibition of incretin degradation, which causes the release of glucagon to be inhibited, thereby increasing insulin secretion, chlorogenic acid involved in INSR network as PTP1B inhibitor. Keyword : Andrographis paniculata, cytoscape, diabetes mellitus type-2, network pharmacology, DPP4 inhibitor, PTP1B inhibitor

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Andrographis paniculata, cytoscape, diabetes mellitus type-2, network pharmacology, DPP4 inhibitor, PTP1B inhibitor
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	21 Jul 2022 03:58
Last Modified:	21 Jul 2022 03:58
URI:	http://repo.setiabudi.ac.id/id/eprint/4963

Actions (login required)

View Item