UJI AKTIVITAS SITOTOKSIK EKSTRAK DAN FRAKSI KULIT BATANG FALOAK (Sterculia quadrifida R.Br) TERHADAP SEL KANKER HEPAR HEPG2

Surapati, Kadek Violanita Putri (2021) UJI AKTIVITAS SITOTOKSIK EKSTRAK DAN FRAKSI KULIT BATANG FALOAK (Sterculia quadrifida R.Br) TERHADAP SEL KANKER HEPAR HEPG2. Skripsi thesis, Universitas Setia Budi.

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Abstract

Liver cancer is one of the diseases that cause high mortality in Indonesia. Conventional liver cancer treatment has several weaknesses so that research is developed on natural ingredients that have cytotoxic effects, one of which is faloak bark (Sterculia quadrifida R.Br). This study was conducted to examine the cytotoxic activity of the extract and fraction of faloak stem bark on HepG2 liver cancer cells. The ethanol extract of faloak stem bark was fractionated using a liquid-liquid extraction method with solvents n-hexane, diethyl ether, and ethyl acetate. The extract and bark fraction of faloak were then tested for their cytotoxic activity against HepG2 liver cancer cells using the MTT method. The results of the cytotoxic test in the form of uptake responses were converted into percent of cell life and continued analysis to determine linear regression between the log concentration of the test sample versus percent of live cells using Microsoft Excel 2010. Cytotoxic activity test showed cytotoxic activity owned by bark extracts and fractions faloak with IC50 extract 89.040 mg / mL, the fraction n-hexane 162.930 mg / mL, ethyl acetate fraction of 55.081 mg / mL, and the fraction of water 74.645 mg / mL. The ethyl acetate fraction had the best activity with the class of compounds contained in the ethyl acetate fraction being flavonoids, alkaloids, and anthraquinones. Keywords: Stercuila quadrifida R.Br, stem bark, cytotoxic, liver cancer, HepG2 cells

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Stercuila quadrifida R.Br, stem bark, cytotoxic, liver cancer, HepG2 cells
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	21 Jul 2022 04:00
Last Modified:	21 Jul 2022 04:00
URI:	http://repo.setiabudi.ac.id/id/eprint/4988

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