UJI AKTIVITAS ANTIDIABETES EKSTRAK ETANOL DAUN KECOMBRANG (Nicolaia speciosa) DAN PENGARUHNYA TERHADAP AKTIVITAS SUPEROKSIDA DISMUTASE (SOD) PADA MENCIT DIABETES YANG DIINDUKSI ALOKSAN

Nurrizki, Noni (2021) UJI AKTIVITAS ANTIDIABETES EKSTRAK ETANOL DAUN KECOMBRANG (Nicolaia speciosa) DAN PENGARUHNYA TERHADAP AKTIVITAS SUPEROKSIDA DISMUTASE (SOD) PADA MENCIT DIABETES YANG DIINDUKSI ALOKSAN. Skripsi thesis, Universitas Setia Budi.

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Abstract

Kecombrang plants contain bioactive compounds such as alkaloids, flavonoids and saponins which have the ability to act as antioxidants so that they can reduce blood glucose levels and increase superoxide dismutase (SOD) activity.The purpose of this research is to determine the antidiabetic activity, superoxide dismutase (SOD) activity, and the effective dose of ethanol extract of kecombrang leaves which can reduce blood glucose levels and increase the activity of superoxide dismutase (SOD) in alloxan-induced diabetic mice. This study used 6 groups namely the normal group, the negative control group (CMC-Na 0.5%), the positive control group (glibenclamide), 96% ethanol extract of kecombrang leaves at a dose 2,8 mg/20 gBB mice; 5,6 mg/20 gBB mice; dan 11,2 mg/20 gBB mice. Ethanol extract of kecombrang leaves was prepared using the maceration method.The test preparation is given orally for 14 days. In this research, measurements of mice body weight, decreased blood glucose levels and superoxide dismutase (SOD) activity. The results showed that 96% ethanol extract of kecombrang leaves could reduce blood glucose levels and increase SOD activity. The most effective dose in reducing blood glucose levels in mice and increasing SOD activity was a dose of 11.2 mg/20 gBB in mice, which was not significantly different from the positive control of glibenclamide (p>0.05). Key words : Nicolaia speciosa, antihiperglikemia, antioxidants, superoxide dismutase (SOD)

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Nicolaia speciosa, antihiperglikemia, antioxidants, superoxide dismutase (SOD)
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	29 Jul 2022 07:47
Last Modified:	29 Jul 2022 07:47
URI:	http://repo.setiabudi.ac.id/id/eprint/5018

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