Saputra, Edo Dwi (2021) FORMULASI DAN UJI AKTIVITAS ANTIBAKTERI Streptococcus mutans PASTA GIGI GEL EKSTRAK DAUN SUKUN (Artocarpus altilis) DENGAN VARIASI KONSENTRASI KARBOPOL 940 SEBAGAI GELLING AGENT. Skripsi thesis, Universitas Setia Budi.
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Abstract
Dental caries is a disease that is damage to the hard tissues and they are characterized by the destruction of enemale or dectin, the dental damage is result from products that are produced by S.mutans bacteria. Breadfruit leaf contains many compounds there are flavonoid, alkaloid, saponin and tannin that use for antibacteria. Formulation of gel toothpaste with extract of natural ingredients need gelling agent carbopol 940 with range 0.5-2 %. This study aimed to determine the effect of variations in the concentration of carbopol 940 on physical quality and antibacterial activity of gel toothpaste. Breadfruit leaf extract was obtained by maceration method. Breadfruit leaf extract with a concentration of 20% was formulated into six formulas of gel toothpaste there were three as controls and three controls with extract breadfruit leaf and 3 variations concentration of carbopol 940 there were 0,5; 1; and l,5g. The gel toothpaste preparation was evaluated for physical quality for 21 days, stability test for 6 cycles and antibacterial activity S.mutans was used diffusion method. The result obtained were analyzed with the shapiro-wilk statistics, and was continued by one way ANOVA/Kruskal walis test, then used paired t test/Wilcoxon. The result showed that increasing the concentration of carbopol 940 decreased the dispersion area but increased the viscosity, pH and vice versa. As well as the preparation of breadfruit leaf extract toopaste with a variation of carbopol 940 has antibacterial activity with inhibition zones of 21,50; 22,50; and 22,87 mm, respectively. Keyword : S. mutans, carbopol 940, gel toothpaste, breadfruit leaf extract.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | S. mutans, carbopol 940, gel toothpaste, breadfruit leaf extract. |
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Fakultas Farmasi > Prodi S1 Farmasi |
| Depositing User: | Tifany Nur Arfiana |
| Date Deposited: | 29 Sep 2022 04:39 |
| Last Modified: | 29 Sep 2022 04:39 |
| URI: | http://repo.setiabudi.ac.id/id/eprint/5288 |
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