FORMULASI DAN UJI AKTIVITAS ANTIBAKTERI SEDIAAN GEL EKSTRAK DAUN BANDOTAN (Ageratum conyzoides L.) TERHADAP BAKTERI Staphylococcus epidermidis ATCC 12228

Sari, Nilam Candra (2022) FORMULASI DAN UJI AKTIVITAS ANTIBAKTERI SEDIAAN GEL EKSTRAK DAUN BANDOTAN (Ageratum conyzoides L.) TERHADAP BAKTERI Staphylococcus epidermidis ATCC 12228. Skripsi thesis, Universitas Setia Budi.

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Abstract

Acne is a condition in which the pores of the skin become blocked so that it will cause red bumps filled with pus, caused by various factors such as inflammation, increased sebum production, and infection of Staphylococcus epidermidis ATCC 12228 bacteria. Bandotan plant (Ageratum conyzoides L.) has been studied as an antibacterial. The purpose of this study was to determine the antibacterial activity of bandotan leaves against Staphylococcus epidermidis and to determine the effect of HPMC and carbopol 940 on the stability and physical properties of gel preparations. Bandotan leaf powder was macerated using 96% ethanol as solvent. The extract was formulated in the form of a gel with various combinations of HMPC and carbopol 940 in a ratio of 1,5:2 (Formula I), 1,75:1,75 (Formula II), 2:1,5 (Formula III), 2,25:1,25 (Formula IV), and 2,5:1 (Formula V). Antibacterial activity test was carried out using the well method. Evaluation of the preparation includes organoleptic test, homogenity test, pH test, viscosity test, dispersion test, adhesion test, and stability test. Analysis used SPSS version 25 program with One-Way ANOVA test to determine the significant value in Formula I, II, III, IV, and V. The best formula for gel preparations for bandotan leaf extract (Ageratum conyzoides L.) with various combinations of gelling agent HPMC and carbopol 940, namely formula IV with a concentration of 1.25% carbopol and 2.25% HPMC as a gelling agent which has an inhibitory power of 16, 31 mm with a strong category and physical quality in accordance with the requirements. Keyword : Ageratum conyzoides L., Acne, Gel, Gelling agent, Staphylococcus epidermidis.

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Ageratum conyzoides L., Acne, Gel, Gelling agent, Staphylococcus epidermidis.
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	10 Oct 2022 07:31
Last Modified:	10 Oct 2022 07:31
URI:	http://repo.setiabudi.ac.id/id/eprint/5377

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