Maharani, Dian (2022) PENGARUH VARIASI PROPILEN GLIKOL DAN GLISERIN SEBAGAI PENETRATION ENHANCER GEL BENZOYL PEROXIDE 2,5% DAN NIACINAMIDE 5% TERHADAP PENYEMBUHAN INFEKSI BAKTERI Staphylococcus epidermidis. Skripsi thesis, Universitas Setia Budi.
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Abstract
Benzoyl peroxide and niacinamide were synthesis compounds that can cure bacterial infections and acne. Penetration enhancers are substances that can increase the diffusion rate of active ingredients. This study used the active ingredients benzoyl peroxide, and niacinamide formulated with variations in the concentration of propylene glycol: glycerin. The first formula added propylene glycol 5% and glycerin 15%; formula two propylene glycol 10% and glycerin 10%; and formula three propylene glycol 15% and glycerin 5%. The purpose of this study was to determine the physical quality and detection of the gel and to determine the effectiveness of the infection gel in male New Zealand White rabbits injected with Staphylococcus epidermidis bacterial suspension. Testing the gel's effectiveness results was based on the speed of infection healing and the subduction of erythema scores. The results of the evaluation of the gel and the effectiveness of healing infections were statistically analyzed using SPSS. Data that were normally distributed and homogeneous with a p value > 0.05 were analyzed using One-way Anova and data with a p value < 0.05 were analyzed using the Kruskal Wallis test and Mann Whitney’s U follow-up test to see the difference between the formulas. The results showed that the addition of penetration enhancer substances could affect the infection healing process in each formula. The 1st formula with the addition of propylene glycol and glycerin (5% : 15%) is the best formula in testing the physical quality and effectiveness of infection healing in reducing the erythema subduction score. Keywords: benzoyl peroxide, niacinamide, penetration enhancer, propylene glycol, glycerin
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | benzoyl peroxide, niacinamide, penetration enhancer, propylene glycol, glycerin |
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Fakultas Farmasi > Prodi S1 Farmasi |
| Depositing User: | Tifany Nur Arfiana |
| Date Deposited: | 30 Nov 2022 04:15 |
| Last Modified: | 30 Nov 2022 04:15 |
| URI: | http://repo.setiabudi.ac.id/id/eprint/5481 |
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