UJI EFEKTIVITAS ANTIDEPRESAN EKSTRAK ETANOL RIMPANG TEMULAWAK (Curcuma xanthorrhiza, Roxb) TERHADAP MENCIT PUTIH JANTAN (Mus musculus) DENGAN METODE TAIL SUSPENSION TEST (TST) DAN OPEN FIELD TEST (OFT)

Kusrifani, Erlyna Idha (2023) UJI EFEKTIVITAS ANTIDEPRESAN EKSTRAK ETANOL RIMPANG TEMULAWAK (Curcuma xanthorrhiza, Roxb) TERHADAP MENCIT PUTIH JANTAN (Mus musculus) DENGAN METODE TAIL SUSPENSION TEST (TST) DAN OPEN FIELD TEST (OFT). Skripsi thesis, Universitas Setia Budi.

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Abstract

Java turmeric contains curcumin which has antidepressant activity by modulating the monoaminergic system by increasing levels of serotonin, norepinephrine and dopamine. This study continues previous research which has proven that the ethanol extract of java turmeric rhizome has antidepressant activity using the forced swimming test method. The purpose of this study was to determine immobility time, locomotor activity in the form of central square duration and grooming duration, and the effective antidepressant dose of java turmeric ethanol extract. This study used two methods, namely observing immobility time using the tail suspension test method and locomotor activity in the form of central square duration and grooming using the open field test method. The test animals used were 25 male white mice with five treatment groups, namely the amitriptyline positive control group, 3 doses of temulawak ethanol extract 7 mg/kg; 14 mg/kg ; 28 mg/kg and the negative control group was CMC Na 0.5%. The results showed that the ethanol extract of java turmeric rhizome at a dose of 28 mg/kg was able to reduce the duration of immobility and increase the locomotor activity of mice by increasing the duration of central square and decreasing the duration of grooming. The dose of java turmeric rhizome ethanol extract that produced the most effective antidepressant effect was a dose of 28 mg/kg. Keywords : Depression, java turmeric, immobility time, locomotor activity

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Depression, java turmeric, immobility time, locomotor activity
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	05 Apr 2023 02:56
Last Modified:	05 Apr 2023 02:56
URI:	http://repo.setiabudi.ac.id/id/eprint/5778

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