Zamzani, Irfan (2016) PENGARUH PEMBERIAN KOMBINASI FRAKSI ETIL ASETAT BUAH PARE (Momordica charantia L.) DAN FRAKSI ETIL ASETAT RIMPANG KUNYIT (Curcuma domestica Val.) TERHADAP KADAR GLUKOSA DARAH DAN EKSPRESI PROTEIN GLUT 4 JARINGAN OTOT PAHA (soleus muscle) PADA TIKUS RESISTENSI INSULIN. Tesis thesis, Universitas Setia Budi Surakarta.
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Abstract
Diabetes mellitus type 2 can be resulted from the tissue insulin resistence accompanied with relative deficiency in insulin secretion. Insulin resistance factor can be due to obesity. The fatty cell also releases TNF resulting in resistance by means of lowering glucose transporter-4 (GLUT-4) expression in the fatty cell and muscle. The treatment of DM Type 2 can be conducted using momordica fruit and turmeric rhizome. The objectives of research were to find out the effect of combination of momordica (Momordica charantia L.) fruit ethyl acetate fraction and turmeric (Curcuma domestica. Val) rhizome ethyl acetate fraction (EAF) on blood glucose level in insulin-resistant rat model and the most optimum combination to reduce glucose level, and to find out the expression of GLUT-4 in insulin-resistance rats’ muscle. The animal insulin resistance was induced by High Fat Diet and fructose. The treatment groups were divided into normal control, negative control (CMC-Na solution 1%), positive control (metformin 45 mg/Kg BW), turmeric EAF (10 mg/200 g BW), momordica EAF (0.4 mg/200g BW), combined turmeric EAF: momordica EAF (5:0.8 mg/200g BW), combined turmeric EAF: momordica EAF (10:0.4 mg/200g BW), and combined turmeric EAF: momordica EAF (20:0.2 mg/200g BW). The result showed that combination of turmeric EAF (ethanol extract fraction) and Momordica EAF (20 mg/200g BW: 0.2 mg/200g BW) exhibited the most optimum effect on lowering the blood glucose level in the rats (48.08%) and exhibited the most optimum effect on increasing the number of GLUT 4 protein (29.474). The result of statistic analysis (p < 0.05) showed that there was a linear relationship between the increased number of GLUT 4 protein and the percentage of lowered blood glucose level. Keywords: ethyl acetate fraction, momordica fruit, turmeric rhizome, blood glucose level, GLUT 4.
| Item Type: | Thesis (Tesis) |
|---|---|
| Uncontrolled Keywords: | Keywords: ethyl acetate fraction, momordica fruit, turmeric rhizome, blood glucose level, GLUT 4. |
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Fakultas Farmasi > Prodi S2 Farmasi |
| Depositing User: | Herera Gadys USB |
| Date Deposited: | 23 Feb 2019 03:23 |
| Last Modified: | 22 Sep 2020 04:31 |
| URI: | http://repo.setiabudi.ac.id/id/eprint/683 |
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