AKTIVITAS ANTIBAKTERI, ANTIDIABETES DAN TERAPI LUKA DIABETIK SEDIAAN TOPIKAL EKSTRAK KOMBINASI POLIHERBAL

Damayantie, Wury (2018) AKTIVITAS ANTIBAKTERI, ANTIDIABETES DAN TERAPI LUKA DIABETIK SEDIAAN TOPIKAL EKSTRAK KOMBINASI POLIHERBAL. Tesis thesis, Universitas Setia Budi Surakarta.

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Abstract

Diabetes mellitus (DM) is a metabolic disorder characterized by hyperglycemia associated with abnormalities of carbohydrate, fat and protein metabolism caused by decreased insulin secretion . This study aims to determine the antibacterial activity against S. aureus and P. aeruginosa, decreased blood glucose levels and polyherbal combination activity in diabetic ulcer healing in STZ-NA-induced rats. This study was conducted using 10 test animals each test group consisted of 5 mice groups: group 1 as a normal control, negative control group II (vaseline, CMC 0.5%, petroleum jelly and CMC 0.5%), Group III positive control group (Glibenclamide, Nebacetin, Glibenclamide & Nebacetin), group VI treatment control (oral), group VII as treatment control (topical), group VIII as treatment control (oral and topical combination). All test animals were induced with STZ 45 mg / kg BW and NA 110 mg / kg BB except in the normal group. The results showed that treatment control (oral and topical combination) with dose of 150 mg / kg BB can decrease glucose level, and can affect the ulcer skin tissue injury in DM male rats. Keywords : Antibacterial, Antidiabetes, poliherbal combination, diabetic ulcers, STZ-NA.

Item Type: Thesis (Tesis)
Uncontrolled Keywords: Antibacterial, Antidiabetes, poliherbal combination, diabetic ulcers, STZ-NA.
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S2 Farmasi
Depositing User: magdalena kartika ningsih
Date Deposited: 25 Feb 2019 03:07
Last Modified: 17 Sep 2020 04:19
URI: http://repo.setiabudi.ac.id/id/eprint/1006

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