AKTIVITAS ANTIHIPERGLIKEMIK EKSTRAK ETANOL DAUN SELIGI (Phyllanthus buxifolius Muell. Arg.) TERHADAP TIKUS PUTIH JANTAN YANG DIINDUKSI DEKSAMETASON

Fa'iza, Nur (2017) AKTIVITAS ANTIHIPERGLIKEMIK EKSTRAK ETANOL DAUN SELIGI (Phyllanthus buxifolius Muell. Arg.) TERHADAP TIKUS PUTIH JANTAN YANG DIINDUKSI DEKSAMETASON. Skripsi thesis, Universitas Setia Budi Surakarta.

	Text SKRIPSI FAIZ.pdf Download (1MB)
	Text INTISARI.pdf Download (70kB)

Abstract

Diabetes mellitus is a group of metabolic diseases with hyperglycemia as the characteristic that occurs due to abnormalities in insulin secretion, impaired insulin action or both. Medical plants with antioxidant potential may be used as an alternative treatment of diabetes. One source of natural antioxidants as antidiabetic seligi leaf (Phyllanthus buxifolius Muell. Arg.) The purpose of this study was to determine the antihyperglycemic activity of the ethanol extract of the seligi leaf and dosages are most effective in lowering blood glucose levels. This study was conducted using 30 male Wistar rats were induced by a single dose dexamethasone 1 mg / kg intramuscularly. This study divided into six groups, each group consisted of 5 rats. Group I: normal control, group II: negative control (dexamethasone), group III: positive control (metformin 45 mg / kg), Group IV, V and V are the groups which are treated with the ethanol extract of seligi leaf with the dose of 196 mg / kg, 392 mg / kg and 784 mg / kg bw. The treatment was given for 14 days. In this study the measurement of blood glucose levels in rats by using glucose oxidase (GOD-PAP). The results of this study showed that the ethanol extract of the seligi leaf which dose of 196 mg / kg, 392 mg / kg and 784 mg / kg bw of body weight can reduce the blood glucose levels of rats. The most effective dose in lowering blood glucose levels of the rats was a dose of 784 mg / kg. Keywords :Seligi leaf, antihyperglycemic, dexamethasone, metformin.

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Seligi leaf, antihyperglycemic, dexamethasone, metformin.
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Herera Gadys USB
Date Deposited:	25 Feb 2019 03:08
Last Modified:	25 Feb 2019 03:08
URI:	http://repo.setiabudi.ac.id/id/eprint/1019

Actions (login required)

View Item