PENGARUH KOMBINASI EKSTRAK AIR LIDAH BUAYA (Aloe vera L) DAN DAUN STEVIA (Stevia rebaudiana Bertoni) TERHADAP AKTIVITAS ENZIM GLUTATION PEROXIDASE DAN GAMBARAN HISTOPATOLOGI HATI PADA TIKUS PUTIH JANTAN YANG DIINDUKSI ALOKSAN

LARASATI, Rine (2018) PENGARUH KOMBINASI EKSTRAK AIR LIDAH BUAYA (Aloe vera L) DAN DAUN STEVIA (Stevia rebaudiana Bertoni) TERHADAP AKTIVITAS ENZIM GLUTATION PEROXIDASE DAN GAMBARAN HISTOPATOLOGI HATI PADA TIKUS PUTIH JANTAN YANG DIINDUKSI ALOKSAN. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Stevia (Stevia rebaudiana Bertoni) and aloe vera (Aloe vera L.) leaf can evidently lower blood glucose level, such as steviosida on stevia leaf and alkaloid compounds, saponins and aloe emodin glycosides in aloe vera. This study aims to determine the combination of these two plants can increase glutathione enzyme activity and repair damage to the liver. This research employed 35 rats divided into 7 groups: I normal control, II positive control, III negative control, IV stevia leaf extract 400 mg/ kgBW, V aloe vera leaf extract 400 mg/ kgBW, VI combined stevia and aloe vera leaf extracts 25% : 75%, and VII combined stevia and aloe vera leaf extracts 50% : 50%. The administration of tested preparation was conducted per oral for 14 days after having been induced with alloxane 140 mg/kg BW. The observation on glutation peroxidase enzyme was conducted after extract administration treatment by taking liver organ in tested animal. The result of measurement on the improvement of glutation peroxidase enzyme activity and repair of liver cell damage. The highest effect was obtained on a single extract of aloe vera and a combination of 25% stevia: aloe vera 75%, but its potential improvement was lower than positive control (glibenclamide). Keywords: stevia leaves, aloe vera leaves, GPx, liver histopathology

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: stevia leaves, aloe vera leaves, GPx, liver histopathology
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S1 Farmasi
Depositing User: Tifany Nur Arfiana
Date Deposited: 25 Feb 2019 03:26
Last Modified: 25 Feb 2019 03:26
URI: http://repo.setiabudi.ac.id/id/eprint/1142

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