KARAKTERISASI DAN OPTIMASI SOLID SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM (S-SNEDDS) ANALOG KURKUMIN TERHADAP ADSORBEN AEROSIL DENGAN METODE SIMPLEX LATICE DESIGN (SLD)

SULISTIANA, Sulistiana (2018) KARAKTERISASI DAN OPTIMASI SOLID SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM (S-SNEDDS) ANALOG KURKUMIN TERHADAP ADSORBEN AEROSIL DENGAN METODE SIMPLEX LATICE DESIGN (SLD). Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Curcumin analog is derivate compound of curcumin that is result by Curcuma Longa extract that has many potential biological and pharmachological activities such as anti-tumor, anti inflamasi, anti virus, antioxidant, and anti HIV, that is dificult to solve in water. The making process of SNEDDS curcumin analog that used olive oil, tween 80, and PEG 400 composition that can solve those symptoms by forming nanoemulsion o/w in digestive system. The stability of SNEDDS curcumin analog can be increased by adding adsorben aerosil. The optimum formula of SNEDDS curcumin analog was reached by using simplex latice design in design expert 7.1.5. Critical point parameters that included emulsification time, drug load, percentage transmittance were analyzed by using one sample t test. Then, they were made in solid form by adding aerosil adsorben by using adsorption solid to carier, and were characterized based on emulsification time, drug load, percentage transmittance, dissolution, particle size, and FT-IR. The optimum foemula of SNEDDS curcumin analog resulted pure and homogeneous mixture consisted of 0.4 mL of olive oil, 1.1 mL tween 80 and 0.5 mL PEG 400. The nanoemulsion of curcumin analog had 10.6767 ± 0.239 second emulsification time, 35, 1600 ± 0.144 ppm drug load, and 50.5600 ± 0.149% transmittance. The solid SNEDDS powder formed nanoemulsion had 59,33 ± 1,30 second emulsification time, 37,74 ± 0,00 ppm drug load, transmittance 37,92 ± 0,20%, and particle size 154,2 ± 20,2 nm, rendement of SNEDDS solid powder 96,29%, solid dissolution test of SNEDDS analog curcumin on buffer phosphate media pH 6,8 reached 97,99% in 5 minutes was higher 14,39% than pure curcumin analog. Moreover, the result of the spectra FT-IR aerosil can become carrier subtance of SNEDDS curcumin analog. Keywords: curcumin analog, solid SNEDDS, aerosil, simplex lattice design

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	curcumin analog, solid SNEDDS, aerosil, simplex lattice design
Subjects:	R Medicine > RV Botanic, Thomsonian, and eclectic medicine
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	25 Feb 2019 03:35
Last Modified:	25 Feb 2019 03:35
URI:	http://repo.setiabudi.ac.id/id/eprint/1192

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