UJI TOKSISITAS SUBKRONIS MINYAK BIJI MAHONI (Swietenia macrophylla King) TERHADAP KADAR BLOOD UREA NITROGEN DAN KADAR KREATININ SERTA GAMBARAN HISTOPATOLOGI ORGAN GINJAL PADA TIKUS PUTIH (Rattus norvegicus)

Witney, Ruvanie (2017) UJI TOKSISITAS SUBKRONIS MINYAK BIJI MAHONI (Swietenia macrophylla King) TERHADAP KADAR BLOOD UREA NITROGEN DAN KADAR KREATININ SERTA GAMBARAN HISTOPATOLOGI ORGAN GINJAL PADA TIKUS PUTIH (Rattus norvegicus). Skripsi thesis, Universitas Setia Budi Surakarta.

[img] Text
INTISARI_ABSTRAK.pdf
Download (89kB)
[img] Text
2017_ 19133785A (Skripsi).pdf
Download (5MB)

Abstract

Mahogany seed is one of the herbs that are used as anti-diabetic in traditional medicine. This research aims to determine the effect of Subchronic toxicity towards toxic symptoms and the level of Blood Urea Nitrogen (BUN), and creatinin, also the histopathology image of kidney in rats. Mahogany seeds oil was obtained using hydraulic press device. The research used 50 male and 50 female rats that were divided into 5 groups, 1 group of negative control administreated by aquadestilata and 4 treatment groups treated by mahogany seeds oil at dose 300 mg/KgBW, 600 mg/KgBW, and dose 900 mg/KgBW, and satellite group were treated with the same dose as 900 mg/KgBW. This research was observated for 90 days and additional 28 days for satellite group to observe the reversible effect. The examination of BUN and Creatinin were exam once every 30 days. The end of observation animals was sacrificed for the histopathological test. The result revealed that the mahogany seed oil treatment increase the body weight of male rats in dose 300 mg/KgBw, 600 mg/KgBW, and 900 mg/KgBW and female rats in dose 900 mg/KgBW and caused toxic effects showed edema on female rats in dose 900 mg/kgBW, changed the BUN level and also kidney histopathology image. Keywords: Mahogany Seed oil (Swietenia macrophylla King), Subchronic toxicity, Kidney histopathology.

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: Mahogany Seed oil (Swietenia macrophylla King), Subchronic toxicity, Kidney histopathology.
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S1 Farmasi
Depositing User: Herera Gadys USB
Date Deposited: 25 Feb 2019 03:38
Last Modified: 25 Feb 2019 03:38
URI: http://repo.setiabudi.ac.id/id/eprint/1205

Actions (login required)

View Item View Item
Repository USB is powered by EPrints 3 which is developed by the School of Electronics and Computer Science at the University of Southampton. More information and software credits.