PENGARUH PEMBERIAN KOMBINASI EKSTRAK ETANOL 70% DAUN CEREMAI (Phyllanthus acidus (L.) Skeels) DAN KELOPAK BUNGA ROSELLA (Hibiscus sabdariffa L.) TERHADAP KADAR KOLESTEROL TOTAL DAN LDL PADA TIKUS PUTIH (Rattus norvegicus L.) HIPERKOLESTEROLEMIA

CARUTA, Ayu Subhaga Usha (2016) PENGARUH PEMBERIAN KOMBINASI EKSTRAK ETANOL 70% DAUN CEREMAI (Phyllanthus acidus (L.) Skeels) DAN KELOPAK BUNGA ROSELLA (Hibiscus sabdariffa L.) TERHADAP KADAR KOLESTEROL TOTAL DAN LDL PADA TIKUS PUTIH (Rattus norvegicus L.) HIPERKOLESTEROLEMIA. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Ceremai (Phyllanthus acidus (L.) Skeels) leaves and rosella (Hibiscus sabdariffa L.) flower petals are a plant that have been researched antihypercholesterolemic effect. This research aimed to observe the effect of combination extract ethanol ceremai leaves and rosella flower petals on total cholesterol levels and LDL. Thirty-five rats white male wistar strain which was divided into seven groups, is normal control (aquadestilata), hypercholesterolemic control, dose ceremai (45 mg/kg bw), dose rosella(75,6 mg/kg bw), combination extract 1 (11,25mg/ kg bw : 56,7 mg/ kg bw), combination extract 2 (22,5mg/ kg bw : 37,8 mg/ kg bw), and combination extract 3 (33,75mg/ kg bw : 18,9 mg/ kg bw). Rats given induction of high cholesterol and lipid diet (2,5 ml/200 g bw) and propylthiouracil (10 mg/kg bw) for 28 days. Extract administration conducted for 14 days. Measurement of total cholesterol levels and LDL done on the days 0, 28, 35, and 42. Analysis of data conducted using ANOVA statistical test. The result showed that of combination extract ethanol ceremai leaves and rosella flower petals can lower total cholesterol and LDL significantly (α < 0,05). Combination extract 2, extract ceremai leaves 22,5 mg/ kg bw and rosella flower petals 37,8 mg/ kg bw was more effective in reduce total cholesterol levels and LDL. Keywords: Combination, ceremai leaves, rosella flower petals, total cholesterol levels, LDL.

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Combination, ceremai leaves, rosella flower petals, total cholesterol levels, LDL.
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	26 Sep 2019 08:35
Last Modified:	26 Sep 2019 08:35
URI:	http://repo.setiabudi.ac.id/id/eprint/1325

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