OPTIMASI PROPORSI FAST DISINTEGRATING TABLET PIROKSIKAM DENGAN KOMBINASI SUPERDISINTEGRANT EXPLOTAB® DAN BAHAN EFFERVESCENT DENGAN METODE SIMPLEX LATTICE DESIGN

SARI, Enggar Vivi Pratama (2016) OPTIMASI PROPORSI FAST DISINTEGRATING TABLET PIROKSIKAM DENGAN KOMBINASI SUPERDISINTEGRANT EXPLOTAB® DAN BAHAN EFFERVESCENT DENGAN METODE SIMPLEX LATTICE DESIGN. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Fast Disintegrating Tablet (FDT) is one of the innovations in pharmaceutical technology, the rapid disintegration of tablet is less than one minute without water. Piroxicam a small dose medication (10-20mg/day) were included in the BCS class II, with the mechanism action of inhibiting the enzyme cyclooxygenase (COX-2) in the treatment of rheumatoid arthritis and osteoarthritis. This study aims to determine the effect combination superdisintegrant Explotab® with effervescent component toward physical properties and dissolution of FDT piroxicam. FDT piroxicam with Simplex Lattice Design method created three formulas with multiple comparison superdisintegrant Explotab®:effervescent component; F1(0%:100%), F2(50%:50%) and F3(100%:0%). Determining the optimum formula using Design Expert®6.0.8 software with critical point hardness, friability, upon wetting, disintegration time in vitro;in vivo, dissolution Q1;DE5 and response tester. Analysis software optimum formula predicted and the experimental result were compared using SPSS One Sample t-test. Superdisintegrant Explotab® with effervescent component (citrat.acid:sod.bicarbonat) combination increases the hardness, friability, disintegration time in vitro and disintegration time in vivo, however reduce the wetting time, dissolution time Q1 and DE5 tablet with a response taste F1 95%, F2 45% and F3 90% sweetness. The result showed optimum formula FDT piroxicam proportion of superdisintegrant Explotab® 39,64% and effervescent components 60,36%. The result of optimum formula was not significantly different between the prediction software with the experimental result p>0,05. Key words : Fast Disintegrating Tablet Piroxicam, Explotab®, Effervescent, Simplex Lattice Design

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Fast Disintegrating Tablet Piroxicam, Explotab®, Effervescent, Simplex Lattice Design
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	30 Sep 2019 04:09
Last Modified:	30 Sep 2019 04:09
URI:	http://repo.setiabudi.ac.id/id/eprint/1363

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