FORMULASI GEL EKSTRAK DAUN BELUNTAS (Pluchea indica Less.) SEBAGAI ANTIOKSIDAN DENGAN KOMBINASI GELLING AGENT KARBOPOL 940 DAN CMC-Na

INDRIYANA, Indriyana (2016) FORMULASI GEL EKSTRAK DAUN BELUNTAS (Pluchea indica Less.) SEBAGAI ANTIOKSIDAN DENGAN KOMBINASI GELLING AGENT KARBOPOL 940 DAN CMC-Na. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Beluntas leaves (Pluchea indica Less.) has antioxidant activity because they contain phytochemical compounds such as tannins, sterols, hydroquinone, and flavonoids. Antioxidants are best applied in the preparation of gel. The aims of this study to gel formulation of beluntas leaf extract variation of concentration carbopol 940 and CMC-Na as well as determine the gel beluntas leaf extract has antioxidant activity. Beluntas leaves extract was obtained by maceration method. Gel of beluntas leaves extract was made in five formulas with variations concentration of carbopol 940 and CMC-Na. The obtained gel was tested its stability and physical quality properties consisting organoleptic, homogeneity, viscosity, pH. The antioxidant activity was tested by with DPPH method. The results showed that IC50 values of the extracts, the formula 1 to 5 respectively, were 9.376 ppm; 91.833 ppm; 85.901 ppm; 84.528 ppm; 85.310 ppm; 82.035 ppm. The extracts and all formula have strong antioxidant activity. The addition of carbopol 940 and CMC-Na decreased in each formula on the nature of physical quality, stability, and antioxidant activity. The gel with carbopol 940 concentration of 1% and CMC-Na 1% possess physical quality, stability and good antioxidant activity. Keywords: beluntas leaves extract, gel, DPPH, antioxidant

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: beluntas leaves extract, gel, DPPH, antioxidant
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S1 Farmasi
Depositing User: Tifany Nur Arfiana
Date Deposited: 01 Oct 2019 03:13
Last Modified: 01 Oct 2019 03:13
URI: http://repo.setiabudi.ac.id/id/eprint/1386

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