Luthfiyanti, Niken (2016) PENGARUH PEMBERIAN KOMBINASI EKSTRAK ETANOL 70% DAUN BAWANG KUCAI (Allium tuberosum Rottl ex. Spreng) DAN KULIT JERUK MANIS (Citrus sinensis L.) TERHADAP KADAR KOLESTEROL LDL DAN SEL BUSA PADA TIKUS PUTIH (Rattus norvegicus) HIPERKOLESTEROLEMIA. Skripsi thesis, Universitas Setia Budi Surakarta.
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Abstract
Allium tuberosum leaves and sweet orange peel is a part of the plant which have anti-hypercholesterolemia effect. This research aims to know the effectiveness of the combination of Allium tuberosum leaves extract and sweet orange peel extract against LDL cholesterol levels, anti-atherosclerosis effect compared to the doses of each plant and the dose is the most effective combination of extracts. As many as 35 white male rats wistar strain divided into seven groups. Normal control group was given only PAR-S Confeed and aquadestillata. During the 42 days, the control group of hypercholesterol, dose I (Allium tuberosum leaves extract 110 mg/Kg BW), dose II (sweet orange peel extract 50 mg/Kg BW), dose III-V the combination of Allium tuberosum leaves : orange sweet peel, dose III (55mg/Kg BW : 25mg/Kg BW), dose IV (82,5mg/Kg BW : 12,5mg/Kg BW), and dose V (27,5mg/Kg BW : 37,5mg/Kg BW) given the high cholesterol food and propiltiouracil 0.1%. Administering of extracts made during 14 days. Measurement of LDL cholesterol levels done on day 0th, 42nd, and 56th. On day 56th observed histopathology aorta to see the effect of anti-atherosclerosis. The results of this study showed that extract of Allium tuberosum leaves dose of 110 mg/KgBW is most effective for lowering LDL cholesterol levels as well as indicated the existence of a decrease in foam cell and a wall thickness of the aorta in intima tunika to media tunika. While the combination of doses is more effective in lowering LDL cholesterol levels and inhibit foam cell that is a combination dose of Allium tuberosum leaves extract : sweet orange peel extract 82,5mg/Kg BW : 12,5mg/Kg BW. Keyword : Allium tuberosum leaves extract, sweet orange peel extract, LDL cholesterol, foam cell.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | Allium tuberosum leaves extract, sweet orange peel extract, LDL cholesterol, foam cell. |
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Fakultas Farmasi > Prodi S1 Farmasi |
| Depositing User: | Tifany Nur Arfiana |
| Date Deposited: | 01 Oct 2019 03:17 |
| Last Modified: | 01 Oct 2019 03:17 |
| URI: | http://repo.setiabudi.ac.id/id/eprint/1426 |
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