Septiyaningsih, Atin Wulan (2018) EFEK ANTIHIPERGLIKEMIK EKSTRAK ETANOL DAUN SIRSAK (Annona muricata L.) PADA MENCIT JANTAN DENGAN BEBAN AMILUM DAN GLUKOSA. Skripsi thesis, Universitas Setia Budi Surakarta.
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Abstract
Annona muricata L. is one of the medicinal plants that are useful as antidiabetes. Soursop leaf contains flavonoid, alkaloid, saponin and tannin that can inhibit the activity of glucose transporter from the intestine so as to decrease glucose. This study aim to determine the effect and dose of saursop leaf ethanol extract which is effective in reducing blood glucose levels in male mice with the load of amilum and glucose. The method used in this study is load of amilum and glucose load. The animals were divided into 5 groups, each group consisted of 3 tails. Amilum load consisting of group I control negative CMC 0.5%, II positive control of acarbose, III ethanol extract of soursop leaf 140 mg / 20 kg BB mice, IV ethanol extract of soursop leaf 210 mg/20 kg BB mice, V ethanol extract of soursop leaves 280 mg / 20 kg BB mice. The test solution was administered for 3 hours after the induction of the starch load and the measurement was done in the 30th minute and the 180th minute. For glucose load, positive control using glibenclamide given a test solution was carried out for 2 hours in the induction of glucose load and measurement were taken in the 30th, the 120th minute. The data obtained were analyzed by Kolmogorov-Smirnov followed by one-way ANOVA and post hoc test. The results showed that soursop leaf ethanol extracts at a dose of 140 mg/20 kg BB mice, 210 mg/20 kg BB mice and 280 mg /20 kg BB mice, weight of mice the control of drug comparison. The effective dose at starch and glucose method is 140 mg/20 kg BB mice. Key words : Amilum and glucose, Annona muricata L., antihyperglycemic, acarbose, glibenclamide.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | Amilum and glucose, Annona muricata L., antihyperglycemic, acarbose, glibenclamide. |
| Subjects: | R Medicine > RV Botanic, Thomsonian, and eclectic medicine |
| Divisions: | Fakultas Farmasi > Prodi S1 Farmasi |
| Depositing User: | Tifany Nur Arfiana |
| Date Deposited: | 22 Feb 2019 07:57 |
| Last Modified: | 22 Feb 2019 07:57 |
| URI: | http://repo.setiabudi.ac.id/id/eprint/145 |
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