OPTIMASI PROPORSI FAST DISINTEGRATING TABLET PIROKSIKAM DENGAN KOMBINASI SUPERDISINTEGRANT CROSCARMELLOSE SODIUM ( AC-DI-SOL ) DAN BAHAN EFFERVESCENT DENGAN METODE SIMPLEX LATTICE DESIGN

SETIANINGSIH, Ria (2016) OPTIMASI PROPORSI FAST DISINTEGRATING TABLET PIROKSIKAM DENGAN KOMBINASI SUPERDISINTEGRANT CROSCARMELLOSE SODIUM ( AC-DI-SOL ) DAN BAHAN EFFERVESCENT DENGAN METODE SIMPLEX LATTICE DESIGN. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Piroxicam is a Non Steroid Anti-Inflammatory Drugs have the efficacy of treatment of rheumatoid arthritis, osteoarthritis and pain. Piroxicam made fast disintegrating tablet to accelerate the disintegration time and give good taste. The aim of research is to determine the concentration and the effect of the combination of superdisintegrant Ac-Di-Sol and effervescent component on the physical properties and drug release. Research using Simplex Lattice Design with a combination of superdisintegrant Ac-Di-Sol and effervescent component made 3 formula. Formula I 100% Ac-Di-Sol : 0% effervescent, Formula II 50% Ac-Di-Sol : 50% effervescent, Formula III 0% Ac-Di-Sol : 100% effervescent. Parameter tipping points include hardness, friability, upon wetting, disintegration time in vitro, in vivo disintegration time, Q1 and DE5. The result included a critical point 8.0.6 Design Expert program to get the optimum formula. The result showed an increase in Ac-Di-Sol increases hardness, friability and down time of the wetting, disintegration time in vitro, in vivo disintegration time, Q1 and DE5. Increased effervescent increasing violence, upon wetting, disintegration time in vitro, in vivo disintegrationtime, Q1, DE5 and lower brittleness. The combinationof these two components are increase the in vivo disintegration time and lower the hardness, friability, upon wetting, disintegration time in vitro, Q1 and DE5. Simplex Lattice Design method produces the optimum formula by comparison superdisintegrant Ac-Di-Sol 9,17% and 90,83 effervescent component. Key words : fast disintegrating tablet (FDT) piroxicam, Ac-Di-Sol, Effervescent, Simplex Lattice Design.

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	fast disintegrating tablet (FDT) piroxicam, Ac-Di-Sol, Effervescent, Simplex Lattice Design.
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	01 Oct 2019 03:24
Last Modified:	01 Oct 2019 03:24
URI:	http://repo.setiabudi.ac.id/id/eprint/1462

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