YANTI, Wiwik Ida (2016) OPTIMASI ORALLY DISINTEGRATING TABLETS (ODTs) KETOPROFEN MENGGUNAKAN SUPERDISINTEGRANT CROSPOVIDONE DAN KOMPONEN EFFERVESCENT DENGAN METODE FACTORIAL DESIGN. Skripsi thesis, Universitas Setia Budi Surakarta.
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Abstract
Ketoprofen is a propionate acid derivate use to treatment of non-steroid anti inflammatory drugs (NSAIDs) analgetic, antipirettan and anti-inflammatory. According to the Biopharmaceutics Classification System (BCS) ketoprofen is included in second classes drug which have low solubility and high permeability, Ketoprofen, is very insoluble in water causes a low dissolution rate, dissolution rate is a limiting factor the rate of drug absorption and have low bioavailability. The orraly disintegrating tablets (ODTs) ketoprofen will disintegrate or dissolve rapidly in the saliva without the need for water and furthermore it was intended to give rapid therapeutic action. This research purposed to optimize the influence of combination crospovidone and effervescent components which have function as disintegrant, toward physical properties and drug release with factorial design method. Orally disintegrating tablets were prepared by direct compression method and it was evaluated for physical properties of powder and tablet, and drug release. Optimization the formula was carried out by 22 factorial design method with crospovidone and effervescent component as independent variables. Optimum formula was determined by superimposed counter plot using sofware Design Expert 8.0.6 trial version based on tablets properties i.e hardness, friability, disintegration time in vitro and in vivo, wetting time, and amount of drug release during 1 minute. This research was found that effervescent components was the most dominant factor had an affect on disintegration time and amount of drug release than crospovidone. Enhancement effervescent components affected on increase disintegration time of tablet and decrease amount of drug release. Based on superimposed counter plot, optimum formula was achieved with combination crospovidone 4,00 mg and effervescent components 5,65 mg. Keywords : Ketoprofen, ODTs, crospovidone, effervescent components, factorial design.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | Ketoprofen, ODTs, crospovidone, effervescent components, factorial design. |
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Fakultas Farmasi > Prodi S1 Farmasi |
| Depositing User: | Tifany Nur Arfiana |
| Date Deposited: | 01 Oct 2019 03:31 |
| Last Modified: | 01 Oct 2019 03:31 |
| URI: | http://repo.setiabudi.ac.id/id/eprint/1508 |
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