ARINI, Anggi Afi (2015) OPTIMASI FORMULA KRIM MINYAK ATSIRI DAUN ROSEMARY (Rosmarinus officinalis L) SEBAGAI ANTIBAKTERI DENGAN KOMBINASI EMULGATOR TWEEN 60 DAN SPAN 60 MENGGUNAKAN METODE DESAIN FAKTORIAL. Skripsi thesis, Universitas Setia Budi Surakarta.
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Abstract
Rosemary leaf (Rosmarinus officinalis L) contains volatile oils which have activity as antibacterial. The use of volatile oil directly is uneffective, so it was made in the form of cream. The stability of the cream preparation is influenced by emulgator. The aim of this study was to get the optimum formula of Rosemary leaf volatile oil cream using tween 60 and span 60 emulgator with factorial design method and to find out antibacterial activity against Staphylococcus aureus ATCC 25923. Rosemary leaf volatile oil isolated by water distillation method. Rosemary leaf volatile oil cream was made into four formula based on factorial design. The obtained cream were tested for the physical characteristics include viscosity, spreading ability, adhesivity and physical stability during one month and then the factorial design equalization was made by Design Expert version 8.0.6.1 to determine the optimum formula. The obtained data predicted was compared with the experimentation result using T-test. The antibacterial activity of the optimum formula was tested by diffusion method. Optimum formula of Rosemary leaf volatile oil cream was obtained from the proportion of 0,73 Tween 60 and 5,47 Span 60. The validation t-test result indicated that it did not have significant differentiation between predict percentage and the experimentation result. Antibacterial activity of optimum formula resulted 17,3 mm inhibition zone. Keyword : Rosemary Leaf, Factorial Design, Tween 60, Span 60, Staphylococcus aureus ATCC 25923.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | Rosemary Leaf, Factorial Design, Tween 60, Span 60, Staphylococcus aureus ATCC 25923. |
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Fakultas Farmasi > Prodi S1 Farmasi |
| Depositing User: | Tifany Nur Arfiana |
| Date Deposited: | 01 Oct 2019 03:33 |
| Last Modified: | 01 Oct 2019 03:33 |
| URI: | http://repo.setiabudi.ac.id/id/eprint/1529 |
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