UJI AKTIVITAS ANTIHIPERKOLESTEROLEMIA GRANUL KOMBINASI EKSTRAK ETANOL DAUN JATI BELANDA (Guazuma ulmifolia, L) dan KELOPAK BUNGA ROSELLA (Hibiscus sabdarifa, L) TERHADAP KADAR KOLESTEROL TOTAL PADA TIKUS PUTIH HIPERLIPIDEMIA

KLAU, Maria Happy Chistian (2015) UJI AKTIVITAS ANTIHIPERKOLESTEROLEMIA GRANUL KOMBINASI EKSTRAK ETANOL DAUN JATI BELANDA (Guazuma ulmifolia, L) dan KELOPAK BUNGA ROSELLA (Hibiscus sabdarifa, L) TERHADAP KADAR KOLESTEROL TOTAL PADA TIKUS PUTIH HIPERLIPIDEMIA. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

People like to consume high fat food that may increase cholesterol level which can lead to hypercholesterolemia. Due to modern treatment of this disease require relatively high cost, it is necessary to alternate from natural materials e.g. teak leaf and roselle petal extracts. The purpose of this study was to determine antihypercholesterolemia activity of teak leaf and roselle petal extracts single or in combination. Teak leaf and roselle petal was made granules preparation by wet granulation method. The granules were treated to hyperlipidemia white mice. Total 36 white mice were divided into 6 dosage treatment groups i.e. groups I and III were given single dosage granule of teak leaf and roselle petal extracts at dose of 1000 mg/kgBW, and 500 mg/kgBW, group III was given combination dosage of teak leaf 500 mg/kgBW and roselle petal 250 mg/kgBW, group IV was given comparable dosage of simvastatin 0.18 mg/kgBW mice, group V hyperlipid control was given granule preparation which did not contain active substance, group VI negative control was given distilled water and regular feed. Total cholesterol levels were measured by easy touch. Data cholesterol levels obtained were statistically analyzed using SPSS. The results showed that administration single dosage of teak leaf dosage of 1000 mg/kgBW, roselle petal dosage of 500 mg/kgBW, and combination dosage of teak leaf 500 mg/kgBW and roselle petal 250 mg/kgBW could decrease total cholesterol levels. Combination preparation was more effective than single dosage as anticholesterol. Keywords: antihypercholesterolemia, teak leaf, roselle petal

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	antihypercholesterolemia, teak leaf, roselle petal
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	01 Oct 2019 03:46
Last Modified:	01 Oct 2019 03:46
URI:	http://repo.setiabudi.ac.id/id/eprint/1574

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