AKTIVITAS ANTIHIPERGLIKEMI EKSTRAK ETANOL DAUN SIRIH MERAH (Piper crocatum Ruiz & Pav.) DAN EFEKNYA TERHADAP EKSPRESI GLUT-2 PADA TIKUS YANG DIINDUKSI STREPTOZOTOSIN-NIKOTINAMIDA

KUSUMA, EKA WISNU (2016) AKTIVITAS ANTIHIPERGLIKEMI EKSTRAK ETANOL DAUN SIRIH MERAH (Piper crocatum Ruiz & Pav.) DAN EFEKNYA TERHADAP EKSPRESI GLUT-2 PADA TIKUS YANG DIINDUKSI STREPTOZOTOSIN-NIKOTINAMIDA. Tesis thesis, Universitas Setia Budi Surakarta.

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Abstract

Diabetes mellitus is a metabolic disease characterized by hyperglycemia, decreased expression of GLUT-2 in pancreatic, and increased expression of GLUT-2 in liver. Red betel leaf seed is useful for treatment of diabetes. This study aims to determine the effect of antihyperglycemic, increased expression of GLUT-2 in pancreas, and decrease in liver of the red betel leaf ethanol extract in STZ-NA induced rats. This research used 25 male white wistar rats, which randomly divided into five groups, normal control, negative control, positive control, EEDSM dose of 50 mg/kg bw and 100 mg/kg bw. Induced STZ-NA days 0, measured glucose levels next day 5 and treated were for 14 days. Measured parameters were glucose levels, GLUT-2 expression in pancreas and liver. Data glucose levels were analyzed by one way Anova statistical test, significance (P)<0.05 followed by Tukey HSD. The results showed that EEDSM dose of 50 mg/kg bw and 100 mg/kg bw for 14 days can lowed blood glucose levels significantly (p<0,05) compare to the negative control. EEDSM for 14 days qualitatively able to increase the expression of GLUT-2 in pancreatic cells with those in the normal control, negative control, positive control, EEDSM 50 mg/kg bw, and 100 mg/kg bw respectively to 100%, 32,31%, 67,67%, 52,73% and 60,01%. EEDSM qualitatively able to reduce the expression of GLUT-2 in liver cells with those in the normal control, negative control, positive control, EEDSM 50 mg/kg bw, and 100 mg/kg bw respectively to 13,21%, 100%, 52,05%, 87,08%, dan 78, 09%. Key Word: Piper crocatum Ruiz & Pav, antihyperglycemic, STZ-NA, GLUT-2 expression

Item Type:	Thesis (Tesis)
Uncontrolled Keywords:	Piper crocatum Ruiz & Pav, antihyperglycemic, STZ-NA, GLUT-2 expression
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S2 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	20 Nov 2019 04:36
Last Modified:	20 Nov 2019 04:36
URI:	http://repo.setiabudi.ac.id/id/eprint/2115

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