AKTIVITAS ANTIHIPERGLIKEMIK EKSTRAK AIR DAUN SUKUN (Artocarpus altilis (Park.) Fosberg) TERHADAP TIKUS DIABETES YANG DIINDUKSI ALOKSAN

Lema, Apriyani Evalina (2014) AKTIVITAS ANTIHIPERGLIKEMIK EKSTRAK AIR DAUN SUKUN (Artocarpus altilis (Park.) Fosberg) TERHADAP TIKUS DIABETES YANG DIINDUKSI ALOKSAN. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Sukun (Artocarpus altilis (Park.) Fosberg) is one of Indonesian plant and used for everyday life. Sukun has several chemical constituents that can be used as a herbal plant, among these saponins, polyphenols, hydrocyanic acid, acetylcholine, tannins, riboflavin and phenol. Sukun leaf is one plant that used for the treatment of diabetic. This study was aimed to determine antihyperglycemic activity of aqueous extract sukun leaf, determine the extract dose which affect on blood glucose level and determine the effect increased in dose of antihyperglycemic activity rats by alloxan induction. The method used alloxan diabetic. Test animal were divided into five groups, consists of five male white rats : Group I diabetic control (CMC 0,5%), Group II comparative control (glibenclamide) at a dose of 0.09 mg/200 g BB rats, and Group III, IV, V given doses of aqueous extract sukun leaf 7 mg/200 g BB rats, 14 mg/200 g BB rats, 28 mg/200 g BB rats. All groups alloxan induced on day 0 (after fasting 16 hours) intraperitoneally. Examination of blood sugar levels performed on days 4, 8 and 12 after administration of the test preparation. The results showed aqueous extract sukun leaf has antihyperglycemic activity. The aqueous extract sukun leaf affect by lowers blood glucose level with an effective dose of 7 mg/200 g BB. The greater the dose of aqueous extract sukun leaf (7 mg/200 g BB rats, 14 mg/200 g BB rats, 28 mg/200 g BB rats) nothing with increased antihyperglycemic effect in significantly. Keywords: (Artocarpus altilis (Park.) Fosberg), diabetic rats, alloxan, antihyperglycemic.

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	(Artocarpus altilis (Park.) Fosberg), diabetic rats, alloxan, antihyperglycemic.
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	18 Feb 2020 04:00
Last Modified:	18 Feb 2020 04:00
URI:	http://repo.setiabudi.ac.id/id/eprint/2276

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