FORMULASI DAN UJI STABILITAS FISIK SUSPENSI ASAM MEFENAMAT DENGAN KOMBINASI SUSPENDING AGENT PGA (Pulvis Gummi Arabici) DAN Na-CMC (Natrium Carboxymethylcellulosum)

Alpons, Chezia Alviony Thessalonicha (2018) FORMULASI DAN UJI STABILITAS FISIK SUSPENSI ASAM MEFENAMAT DENGAN KOMBINASI SUSPENDING AGENT PGA (Pulvis Gummi Arabici) DAN Na-CMC (Natrium Carboxymethylcellulosum). Karya Tulis Ilmiah thesis, Universitas Setia Budi Surakarta.

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Abstract

Mefenamic acid is a non-steroidal anti-inflammatory that insoluble in water so that it is made in preparation of the suspension. This study was aimed to find out how was the influence of suspending agent PGA and Na-CMC on the physical stability properties of Mefenamic acid, as well to find out what concentration that could provide the most excellent stability quality among four formulas. Mefenamic acid suspension was made preparations in four different formulations. Concentrations of the PGA and Na-CMC from formula 1, 2, 3 and 4 are (5,5% and 0,25%); (7% and 0,5%); (8,5% and 0,75%); (10% and 1%). Suspension which has been created then done physical stability quality testing includes of: organoleptic, pH, viscosity, easily whether or not the cast, volume of sedimentation, and redispersibility. The test results of each formulas in analysis using One-Way Anova test followed Post Hoc Tukey Test 95% confidence levels to find out the best suspension formula and stable during storage. The results showed that the concentration of the suspending agent affected on stability quality test suspension. Formula number 3 based on results of testing physical stability quality has the best stability of four suspension formula made with concentrations of suspending agent PGA and Na-CMC are 8,5% and 0,75%. Keyword: Suspension, Mefenamic acid, Suspending agent, PGA, Na-CMC

Item Type: Thesis (Karya Tulis Ilmiah)
Uncontrolled Keywords: Suspension, Mefenamic acid, Suspending agent, PGA, Na-CMC
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi D3 Farmasi
Depositing User: B Supri Yadi
Date Deposited: 20 Feb 2020 03:21
Last Modified: 20 Feb 2020 03:21
URI: http://repo.setiabudi.ac.id/id/eprint/2309

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