AKTIVITAS ANTIULKUS RIMPANG KUNYIT (Curcuma domestica Val.) DENGAN PERBANDINGAN SEDIAAN PERASAN, EKSTRAK ETANOL, DAN PATI PADA TIKUS PUTIH JANTAN GALUR WISTAR YANG DIINDUKSI NATRIUM DIKLOFENAK

AFRIANTI, Windi Septia (2015) AKTIVITAS ANTIULKUS RIMPANG KUNYIT (Curcuma domestica Val.) DENGAN PERBANDINGAN SEDIAAN PERASAN, EKSTRAK ETANOL, DAN PATI PADA TIKUS PUTIH JANTAN GALUR WISTAR YANG DIINDUKSI NATRIUM DIKLOFENAK. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Non-steroidal anti-inflamatory drugs is inflammatory pain medication with ulcer as long-term side effects. Alternative anti-ulcer which can be used are turmeric. Research airned for to know effectivity and supply most effective from squeeze, ethanl extract, and starch as antiulcer. Turmeric made into juice, ethanol extract, and starch, then given to the rat. Rat were 30 devided into 6 groups. Group 1 (normal), group 2 (natrium diclofenac 0,45 mg/200 g), group 3 (sucralfate 18 mg/200 g), group 4 (juice of turmeric 0,448 g/200 g), group 5 (ethanol extract 6,8 mg/200 g), group 6 (starch of turmeric 7,9 mg/200 g) conduced for 7 days. Last day gastric rat has taken then rated the amount and diameter of the ulcer. Index score ulcer tested with kruskall wallis and continued with mann whitney. For looked severity of membrance of the rat carried histopathology. Research result showed starch and ethanol extract have an effect antiulcer. Ethanol extract with dose 6,8 mg/200 g has the most excellent effectiveness than supply another with decrease in amount and diameter of the ulcer, and the microscopic appearance of the stomach that the structure of mucosa seen regularly, not erode up to Muscularis mucosa on wistar rat. Keywords: turmeric, antiulcer, NSAID, juice, ethanol extract, Muscularis mucosa

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: turmeric, antiulcer, NSAID, juice, ethanol extract, Muscularis mucosa
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S1 Farmasi
Depositing User: Mrs NOVI HANDAYANI
Date Deposited: 21 Feb 2020 03:40
Last Modified: 21 Feb 2020 03:40
URI: http://repo.setiabudi.ac.id/id/eprint/2411

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