Alfaruq, Heru Desma (2014) FORMULASI TABLET MUKOADHESIF PROPRANOLOL HCl DENGAN KOMBINASI MATRIKS KARBOPOL DAN KITOSAN. Skripsi thesis, Universitas Setia Budi Surakarta.
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Abstract
Propranolol HCl is an antihypertensive that works on non-selective beta blocker receptor and have a half live of 3-6 hours and 90% absorbed in the gastrointestinal so that it can be modified into slow release preparation with mucoadhesive systems. This study aimed to know that carbopol and chitosan can give effect to the disolution profile and physical properties of a good tablet. This study was conducted on five formulas with carbopol and chitosan matrix comparation of diferent, ie F1 (100%;0%); F2 (75%;25%); F3 (50%;50%); F4(25%;75%); and F5 (0%;100%). Each tablet had a weight of 250 mg and contained propranolol HCl 80 mg. All formulas done by some testing of the flow time humidity, visibility, uniformity of weight, hardness, friability, swelling index, adhesion and disolution test, the data were analized by statistical tests using one way anova. The results showed the influence of the matrix on the physical properties and disolution profile of propranolol HCl mucoadhesive tablets. Increasing proportion of chitosan can increase hardness and reduce brittleness and decrease disolution rate. Formula 4 with the proportion of carbopol and chitosan (25%:75%) was formulas had the best physical properties. Keywords : Propranolol HCl, Carbopol, Chitosan, Mucooadhesif.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | Propranolol HCl, Carbopol, Chitosan, Mucooadhesif. |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Fakultas Farmasi > Prodi S1 Farmasi |
| Depositing User: | Tifany Nur Arfiana |
| Date Deposited: | 19 Feb 2020 06:29 |
| Last Modified: | 19 Feb 2020 06:29 |
| URI: | http://repo.setiabudi.ac.id/id/eprint/2446 |
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