EFEK KOMBINASI EKSTRAK BATANG BROTOWALI (Tinospora crispa L. Miers) DAN DAUN MANGGA (Mangifera indica L.) TERHADAP PENURUNAN GLUKOSA DARAH MENCIT PUTIH JANTAN DENGAN METODE INDUKSI ALOKSAN

Damayanti, Niken Seftina (2014) EFEK KOMBINASI EKSTRAK BATANG BROTOWALI (Tinospora crispa L. Miers) DAN DAUN MANGGA (Mangifera indica L.) TERHADAP PENURUNAN GLUKOSA DARAH MENCIT PUTIH JANTAN DENGAN METODE INDUKSI ALOKSAN. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Diabetes militus (DM) is disease characterized by high blood glucose levels is accompanied by disorders of lipid metabolism of carbohydrates and proteins as results of insulin insufficiency function. The purpose of this reasearch was to determine the effect of stem ekstract brotowali (Tinospora crispa L. Miers) and leaf mango (Mangifera indica L.) to decrease blood glucose male white mice and reasearch was to dose combination brotowali stem and mango leaf extracts of have a blood glucose lowering effect comparable to glibenclamide. Mice were divided 7 treatment groups, each of 5 mice. First group 0,5% CMC (negative control), second group glibenclamide (0,013 mg/kg BB), third group extract stem brotowali (7 mg/kg BB), fourth mango leaf extract (8,4 mg/kg BB), fifth, sixth and seventh extract combination of mango leaf and brotowali stem with a dose of 1,75 mg : 6,3 mg (25% :75%), 3,5 mg : 4,2 mg ( 50% : 50%), and 5,25 mg : 2,1 mg ( 75%: 25%). Examination of blood glucose levels performed on days 0, 1 st, 4th, 8 th. Analysis of the data obtained using one-way ANOVA (p<0,05). Results of statistical analysis showed all treatment groups had significant difference with the negative control group. Dose combination brotowali stem and mango leaf extract 1,75 mg : 6,3 mg (25%:75%), 3,5 mg : 4,2 mg (50%:50%), dan 5,25 mg : 2,1 mg (75%:25%) have a blood glucose lowering effect comparable to positive control (glibenclamide). Keywords: Stem brotowali (Tinospora crispa L. Miers), leaf mango (Mangifera indica L.), Diabetes mellitus, alloxan

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Stem brotowali (Tinospora crispa L. Miers), leaf mango (Mangifera indica L.), Diabetes mellitus, alloxan
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	19 Feb 2020 07:44
Last Modified:	19 Feb 2020 07:44
URI:	http://repo.setiabudi.ac.id/id/eprint/2649

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