Wijaya, Norma Hadi (2014) PENGARUH PEMBERIAN FRAKSI n-HEKSANA EKSTRAK ETANOL BUAH TAKOKAK (Solanum torvum Swartz) TERHADAP AKTIVITAS FAGOSITOSIS PADA MENCIT PUTIH JANTAN Balb/ c DENGAN METODE BERSIHAN KARBON. Skripsi thesis, Universitas Setia Budi Surakarta.
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Abstract
Phagocytosis is a non-specific immune responses, had a role to fight against foreign particles that into the body such as microorganisms, macromolecules including antigens, the cells or tissues are damaged or die. Solanum torvum Swartz (Solanaceae), known as takokak is a medicinal plant which has phagocytosis activity. The purpose of this research is to know the effect of n-hexane fraction of the ethanol extract of fruit S. torvum decreased phagocytosis activity in mice. This research used Balb/c males mice that are divided into 7 groups are negative control CMC 0.5% (group I), methyl prednisolone as Positive control (group II ) with doses of 0.5 mg/kg bw of mice, doses n-hexane fraction of the ethanol extract of fruits S. torvum fruit (group III, IV, V, VI and VII) is 10; 20; 40; 80; 120 mg/kg bw. Mice were given a single dose of sample test for 7 days. On the 8th day, mice were given carbon suspension 0.1 ml/ 20 g bb iv. The blood taken through venous orbitalis and read its absorbance with spectrophotometry Uv-Vis (650 nm). Phagocytosis indexs were analyzed using one way anova test. The results showed that n-hexane fraction of the ethanol extract of fruits S. torvum with dose 10; 20; 40; 80; 120 mg/kg bw decreasing the phagocytosis activity with an phagocytosis index 0.828; 0,588; 0,475; 0,322; 0,240 respectively. The greater the n-hexane fraction of the ethanol extract of the fruit of S. torvum ethanol greater decrease phagocytic activity Keywords: Solanum torvum Swartz, n-hexane fraction, phagocytosis, carbon clearance, methyl prednisolone
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | Solanum torvum Swartz, n-hexane fraction, phagocytosis, carbon clearance, methyl prednisolone |
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Fakultas Farmasi > Prodi S1 Farmasi |
| Depositing User: | Tifany Nur Arfiana |
| Date Deposited: | 19 Feb 2020 07:49 |
| Last Modified: | 19 Feb 2020 07:49 |
| URI: | http://repo.setiabudi.ac.id/id/eprint/2657 |
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