OPTIMASI FORMULA TABLET SUSTAINED RELEASE TEOFILIN DENGAN MATRIKS NATRIUM KARBOKSIMETIL SELULOSA (CMC Na) DAN HIDROKSIPROPIL METILSELULOSA (HPMC) DENGAN METODE SIMPLEX LATICE DESIGN

Pujianti, Pujianti (2014) OPTIMASI FORMULA TABLET SUSTAINED RELEASE TEOFILIN DENGAN MATRIKS NATRIUM KARBOKSIMETIL SELULOSA (CMC Na) DAN HIDROKSIPROPIL METILSELULOSA (HPMC) DENGAN METODE SIMPLEX LATICE DESIGN. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Theophylline has a relatively short half-life is 3-7 hours and the narrow therapeutic index of 10-15 µg / ml and 125 mg dose usage is. Theophylline in tablet dosage formulation sustained release theophylline concentrations are expected to result in a more uniform and the blood peak levels that do not fluctuate. Based on this, research on the manufacture of slow-release theophylline tablets using HPMC and Na-CMC matrix. Interaction between Na-CMC with HPMC very dominant in determining the dissolution of theophylline. This study is based on the method simplex lattice design (SLD) with two matrix components, namely: (100% HPMC), (50% HPMC: 50% Na-CMC), (100% Na-CMC). Flow time, violence and DE360 as a parameter optimization. Then calculated using the design expert to determine the optimum formula. The results showed that theophylline sustained-release preparations can be made, and kombinsi HPMC matrix and Na-CMC affected the physical quality and the release of theophylline tablets. The proportion that produces sustained release theophylline tablets with optimum physical quality is a formula containing 58,33% HPMC and 41,67% Na-CMC. Keywords: Theophylline, sustained release, HPMC, Na-CMC

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Theophylline, sustained release, HPMC, Na-CMC
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	20 Feb 2020 02:22
Last Modified:	20 Feb 2020 02:22
URI:	http://repo.setiabudi.ac.id/id/eprint/2689

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