OPTIMASI FORMULA TABLET LEPAS LAMBAT SALBUTAMOL SULFAT MENGGUNAKAN MATRIK XANTHAN GUM DAN Na-CMC DENGAN METODE SIMPLEX LATTICE DESIGN

Kurniawan, Angga (2013) OPTIMASI FORMULA TABLET LEPAS LAMBAT SALBUTAMOL SULFAT MENGGUNAKAN MATRIK XANTHAN GUM DAN Na-CMC DENGAN METODE SIMPLEX LATTICE DESIGN. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Salbutamol sulphate has a relatively short half-life (2,7 to 5,5 hour). Sustained release formulation can produce more uniform serum concentrations with less fluctuation in peak-trough levels. The physical properties of tablet mass and the release profile of drug from hydrophilic matrices are influenced by properties of matrix components, : CMC-Na (did not show initial burst release), and xanthan gum (free flowing). The research was done with simplex lattice design (SLD) by using 2 component : CMC-Na (A) and xanthan gum (B). Three formula were obtained that are i.e, F1 (100% A : 0% B), F2 (50% A : 50% B), dan F3 (0% A & 100% B). The Optimization parameters of salbutamol sulphate sustained-release were flow time, absorption of water, the compactibility of the tablet mass, and the release rate of salbutamol sulfat. Based on SLD model, equation was obtained for each parameters, by which the optimum formula could be determined. Xanthan gum was the most dominant factor in increasing time flowability of salbutamol tablet mass. CMC-Na was the most dominant factor in incresing compactibility of salbutamol sulphate tablet mass. Kombination xanthan gum and CMC-Na were influence of dissolution rate by salbutamol sustained-release with little bit more xanthan gum, so more efficient release rate and less absorption of water, then time dissolve be made longer. Based on the simplex lattice design data, the comparison of 41,94% CMC-Na and 58,06% xanthan gum was the optimum tablet formula and it’s release pattern followed zero order kinetics. Key words: salbutamol sulphate, CMC-Na, xanthan gum, sustained-release

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	salbutamol sulphate, CMC-Na, xanthan gum, sustained-release
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	magdalena kartika ningsih
Date Deposited:	21 Feb 2020 03:37
Last Modified:	21 Feb 2020 03:37
URI:	http://repo.setiabudi.ac.id/id/eprint/2829

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