OPTIMASI PROPORSI KOMBINASI MATRIKS KARBOPOL 940P DAN HIDROKSI PROPIL METIL SELULOSA K15M PADA SEDIAAN TABLET SUSTAINED RELEASE KAPTOPRIL SECARA SIMPLEX LATTICE DESIGN

Febriani, Tyas Wening (2014) OPTIMASI PROPORSI KOMBINASI MATRIKS KARBOPOL 940P DAN HIDROKSI PROPIL METIL SELULOSA K15M PADA SEDIAAN TABLET SUSTAINED RELEASE KAPTOPRIL SECARA SIMPLEX LATTICE DESIGN. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Captopril is a hypertension drug that has a short t ½ i.e. 2-3 hours, so it needs to be made in a sustained release tablet dosage form in order to obtain an effective concentration. The use of matrix carbopol 940P and HPMC K15M as a matrix on captopril sustained release tablet dosage method is wet granulation tabletting intended to slow drug release. Comparison of the proportions of the two matrices are then used to find the optimum formula for getting sustained release tablets which meet the requirements and follow the drug release according to zero order kinetics. Interaction between matrix carbopol 940P and HPMC K15M improved flow time and hardness, and lowering the value of the friability and drug release. Optimum formula of captopril sustained release tablets could be obtained from equation of simplex lattice design based on flow time parameters, friability, Q60, Q360, and DE360. According to Design Expert software program version 8.0.6.1 optimum formula in this study were obtained on a formula with a combination of carbopol 940P 30.25 mg and 39.75 mg HPMC K15M. Kinetics of drug release at the optimum formula obtained were analyzed using zero-order kinetics, first order, and Higuchi models, obtained correlation coefficient of each 0.9566, 0.8821, and 0.9929. The results concluded that the optimum formula of drug release followed zero order kinetics and drug release profile followed the diffusion mechanism. Keywords: captopril, carbopol 940P, HPMC K15M, Design Expert.

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	captopril, carbopol 940P, HPMC K15M, Design Expert.
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	20 Feb 2020 02:49
Last Modified:	20 Feb 2020 02:49
URI:	http://repo.setiabudi.ac.id/id/eprint/2872

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