UJI DISOLUSI TERBANDING TABLET GLIBENKLAMID MERK DAGANG DAN GENERIK

Rahmawati, Uvita (2014) UJI DISOLUSI TERBANDING TABLET GLIBENKLAMID MERK DAGANG DAN GENERIK. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Glibenklamid has been used in the diabetic treatment. The commercial dosage form available in brand and generic products type both of them have difference in formulation and fabrication. Glibenklamid included in BCS class IV, thus potential to do comparative dissolution test to ensure similarity of the quality properties products. This study aimed to compare the physical properties and dissolution profile. This study used 5 tablets glibenklamid consists of three kinds of brand products and two kinds of generic products. Dissolution test was conducted according to British Pharmacoeia with dissolution tester tipe 2 (paddle method), the speed of rotation 50 rpm, in 900 ml HCl 0,1 Nas medium at 37 ± 0,5ºC. Determination of glibenklamid tablets dissolution using a UV spectrophotometer at 228,6 nm. The results were compared based on physical properties of tablets,Q45, DE60 statistically with one way ANOVA 95% of confidence interval, similarity factor (f2) and difference factor (f1). The result showed that difference brand of glibenklamide tablets provided significant different in hardness, friability, and disintegration time. Difference brand of glibenklamide tablets provided equal dissolution profile based on amount of drug dissolved at 45 minute (Q45) (p>0.05) and dissolution efficiency (DE60) (p>0.05), similary factor within 50-100, and difference factor less than 15. Keywords :Glibenclamid, physical properties, dissolution profile, similarity factor (f2).

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Glibenclamid, physical properties, dissolution profile, similarity factor (f2).
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	20 Feb 2020 02:50
Last Modified:	20 Feb 2020 02:50
URI:	http://repo.setiabudi.ac.id/id/eprint/2873

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