Hudiyana, Hudiyana (2014) EFEK EKSTRAK ETANOL DAUN BELUNTAS (Pluchea indica Less.) TERHADAP HAMBATAN NEKROSIS HATI PADA TIKUS PUTIH JANTAN GALUR WISTAR YANG DIINDUKSI PARASETAMOL. Skripsi thesis, Universitas Setia Budi Surakarta.
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01. INTISARI.pdf Download (90kB) |
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02. HALAMAN JUDUL - BAB I.pdf Download (690kB) |
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06. BAB V - LAMPIRAN.pdf Download (2MB) |
Abstract
Beluntas (Pluchea indica Less.) Is a medicinal plant that contains flavonoids were shown to have antioxidant activity. The purpose of this fieldwork aims to determine the hepatoprotective effect of the ethanol extract of leaves beluntas ( Pluchea indica Less. ) against liver necrosis barriers Wistar strain male rats induced paracetamol and to determine the correlation between the dose of ethanol extract of leaves beluntas ( Pluchea indica Less. ) With hepatoprotective effect against barriers male white rat liver necrosis induced with paracetamol . This study uses maceration extraction method. Rats were used 30 individuals were divided into 6 groups. I as a normal control group were fed only standard. Group II as negative controls were given 1 % CMC suspension and paracetamol 2.5 g / kg. Group III as positive controls were given curcuma 21.6 mg / 200 gBB. Group IV, V and IV as a treatment of ethanol extract of leaves of test solution beluntas 270 mg/200 gBB, 540 mg / gBB 200, 1080 mg / 200 gBB. On day 8, all mice were sacrificed, the liver histopathology rat preparations were made by calculating the percentage of necrosis of liver cells The results obtained were analyzed by One Way ANOVA test. The results showed that the ethanol extract of leaves beluntas have hepatoprotective effect against liver necrosis barriers seen from the percentage of liver cell necrosis in group IV, V and VI are lower and significantly different (p < 0.05) with the negative control group and the ethanol extract of leaves beluntas 1080 mg/200 GBB has the effect of approaching a positive control. There was a relationship between the dose of ethanol extract of leaves beluntas with the ability to inhibit liver cell necrosis. Keywords : Leaves beluntas, paracetamol, liver necrosis, male mice
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | Leaves beluntas, paracetamol, liver necrosis, male mice |
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Fakultas Farmasi > Prodi S1 Farmasi |
| Depositing User: | B Supri Yadi |
| Date Deposited: | 20 Feb 2020 06:11 |
| Last Modified: | 20 Feb 2020 06:11 |
| URI: | http://repo.setiabudi.ac.id/id/eprint/2892 |
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