Wijayanti, Sari (0201) UJI TOKSISITAS SUBKRONIK MINYAK ATSIRI KAYU MANIS (Cinnamomum burmanni Nees ex Bl.) TERHADAP KADAR SGPT DAN SGOT SERTA GAMBARAN HISTOPATOLOGI PADA ORGAN HATI TIKUS PUTIH JANTAN GALUT WISTAR. Skripsi thesis, Universitas Setia Budi Surakarta.
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01. INTISARI.pdf Download (14kB) |
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02. HALAMAN JUDUL - BAB I.pdf Download (977kB) |
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03. BAB II.pdf Download (71kB) |
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05. BAB IV.pdf Download (463kB) |
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06. BAB V - LAMPIRAN.pdf Download (3MB) |
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04. BAB III.pdf Restricted to Repository staff only Download (312kB) | Request a copy |
Abstract
Cinnamon (Cinnamomum burmanni Nees ex Bl.) has various chemical compounds such as cinnamaldehyde, eugenol, safrole which has efficacy in the treatment. Current research on the safety of cinnamon essential oil was still very minimal. This study was aimed to determine the effect of subchronic toxicity of essential oils of cinnamon (Cinnamomum burmanni Nees ex Bl.) to ALT/AST levels and histopathology figures in hepar organ of white male mice and know whether the greater dose also the greater effects of its subchronic toxicity. Subchronic toxicity testing using 20 mice and were divided into 4 groups. Each group was given treatment of essential oils doses, group I: 0.01 ml/200 g BW, group II: 0.02 ml/200 g BW, group III: 0.04 ml/200 g BW and group IV: distilled water. The data were obtained from the examination ALT/AST levels in the week before treatment, weeks 1, 2, 3, 4 and histopathological figures of the hepar at the end of 4th week. The data results of ALT/AST were analyzed using paired sample t test and One Way Annova, for data histopathological results were analyzed using One Way Annova. The results showed that the essential oil of cinnamon (Cinnamomum burmanni Nees ex Bl.) had no subchronic toxicity effect on the hepar of white male mice which seen by examining results of ALT and AST levels and which observed from histopathologic parameters and the greater dose also the the greater effect of subchronic toxicity to the hepar histopathology of white male mice. Keywords: toxicity, cinnamon essential oil, ALT / AST levels and histopathology.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | toxicity, cinnamon essential oil, ALT / AST levels and histopathology. |
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Depositing User: | B Supri Yadi |
| Date Deposited: | 20 Jan 2020 04:40 |
| Last Modified: | 20 Jan 2020 04:40 |
| URI: | http://repo.setiabudi.ac.id/id/eprint/3046 |
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